ESTIV CORPORATE MEMBERS

Our corporate members help to shape the future of innovative toxicology. We are thankful for their ongoing support.


acCELLerate is a specialist for large-scale production and cryopreservation of highly functional assay ready cells. The instant use of cells from a frozen stock became a widely accepted approach which is preferred to the use of continuously passaged cells. Based on 16 years of experience acCELLerate has developed freezing protocols and established well-controlled processes to prepare assay ready Frozen Instant Cells of high quality and robustness. Frozen Instant Cells can be used like a reagent without prior cultivation. acCELLerate provides assay ready cells from multiple cell lines, validated instaCELL bioassay kits, as well as custom cell banks of Frozen Instant Cells with comprehensive documentation to meet specific requirements of the different fields of application.

For more informatiom visit: www.accellerate.me


Altertox Academy is a SME (Small Medium Enterprise) with tailor made trainings as main activity. It provides hands-on training in human-relevant alternative methods and technologies for toxicologists, from a 3R perspective (replacement, reduction and refinement). Among other services, Altertox Academy also provides support as work package leader in training for EU calls.

For more information visit: https://academy.altertox.be/


Epithelix is a leader for in vitro assessment of drug efficacy and toxicity on the human respiratory tract. Epithelix has developed unique 3D in vitro human airway tissues (MucilAir™; SmallAir™ and AlveolAir™) and testing services for studying airway pathologies like Asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Diseases, Bacterial and Viral infections.

For more information visit: www.epithelix.com


EpiSkin Academy created in 2011 is an international program dedicated to promotion and education to alternatives to animal testing methods in toxicology. As a world leader in tissue engineering, EpiSkin Academy is committed to share knowledge and expertise with scientific community to support implementation of in vitro validated methods and development of new methods using human reconstructed tissues. They offer trainings on validated methods and take part in numerous congresses to present the latest advances in these fields. To go further, they are also engaged in several academic programs worldwide to raise awareness and to prepare the next generation of scientists and regulators for the challenges of 21st century toxicology.

For more information visit: https://www.episkin.com/Episkin-Academy


The Fraunhofer-Gesellschaft, headquartered in Germany, is the world’s leading applied research organization. With its focus on developing key technologies that are vital for the future and enabling the commercial exploitation of this work by business and industry, Fraunhofer plays a central role in the innovation process. As a pioneer and catalyst for groundbreaking developments and scientific excellence, Fraunhofer helps shape society now and in the future. Founded in 1949, the Fraunhofer-Gesellschaft currently operates 74 institutes and research institutions throughout Germany.

For more information visit: www.frauhofer.de


MatTek In Vitro Life Science Laboratories, a European subsidiary of MatTek Corporation (USA) produces reconstructed 3D human tissue models in Bratislava, Slovakia since 2011. MatTek develops, validates, and implements animal alternative testing methods and innovative 3D reconstructed human tissue models for more than 3 decades. Our EpiDerm and EpiOcular tissue models are used in regulatory toxicology (OECD, EU guidelines) and address toxicology and efficacy concerns throughout the cosmetics, chemical, pharmaceutical, and household product industries. In addition to these two, there are 11 more ready-to-use, highly reproducible reconstructed 3D human tissue models in the MatTek portfolio. In 2021, MatTek Corporation was acquired by a bioconvergence corporation CELLINK where it continues its mission toward more precise animal-free testing.

For more information visit: http://www.mattek.com


The Regulatory Company aims to guarantee product safety and compliance in a rapidly developing context. They act with in dept toxicological and regulatory knowledge and pursue an effective and efficient way of working in cooperation with regulators, authorities, producers, distributors, brand-owners, service providers and other stakeholders.
To add the highest possible value The Regulatory Company contributes to the entire product lifecycle from information management, regulatory and toxicological perspective, by offering and executing complete services, in close and involved partnership with clients. They work fully digital making use of the latest available technology, making sure the experts can be contacted easily and directly.

For more information visit: https://www.theregulatorycompany.com/


React4life is an Italian startup that developed MIVO® – Multi In Vitro Organ, a patented microphysiological system (MPS) able to reproduce portions of the human body improving the reliability of the testing outcome. It can easily accommodate and cultivate 3D human tissues, organoids or biopsies to suit every testing needs. MIVO® can be used as bioreactor, for enhancing tissues conditions and prolonging lifetime, for advanced drug testing assays on 3D tissues, for discovering new therapeutic approaches, and for basic research, without involving animal use. It is individually blistered, sterile, disposable, immediately ready-to-use.

For more information visit: www.react4life.com


Senzagen is a spin-out company from Lund University, Sweden, with expertise in immunology, technology and genomics. SenzaGen develops, performs and sells animal-free tests for assessing a substance’s capacity to causes allergies. These tests replace animal testing with human cells in test tubes combined with artificial intelligence. As a scientific quality-orientated and innovative international company, SenzaGen supports its clients with stringent quality assessments.
SenzaGen markets, sells and performs the in vitro GARD® sensitization test which is recommended by ECHA and accepted by OECD for validation.

For more information visit: https://senzagen.com


Symrise is a global supplier of fragrances, flavors, food, nutrition and cosmetic ingredients. Its clients include manufacturers of perfumes, cosmetics, food and beverages, pharmaceuticals and producers of nutritional supplements and pet food. Its sales of € 3.5 billion in the 2020 fiscal year make Symrise a leading global provider. Headquartered in Holzminden, Germany, the Group is represented by more than 100 locations in Europe, Africa, the Middle East, Asia, the United States and Latin America. Symrise works with its clients to develop new ideas and market-ready concepts for products that form an integral part of everyday life. Economic success and corporate responsibility are inextricably linked as part of this process. In addition, Symrise has set up an animal testing policy in 2009 that aims to minimize such testing and Symrise is promoting alternative approaches wherever possible.

For more information visit: www.symrise.com

Corporate Members

Affiliated Societies

Memorandum of Understanding