ESTIV Congress > Scientific Programme

Scientific Programme

The scientific program committee has decided to schedule 2 parallel sessions to reflect the high demand for additional scientific, societal and regulatory topics to be discussed at the ESTIV congress.

Themes

Invited Speakers

  • Bio-engineering, stem cells and disease models
  • Models, biomarkers and assays for endocrine disruption and developmental toxicity
  • Models, biomarkers and assays for systemic and immune toxicity
  • Organ-on-chip models
  • Challenges in cosmetic regulation
  • Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning
  • Local toxicity testing (safety and efficacy)
  • Toxicokinetics and in vitro – in vivo extrapolation
  • Animal product free NAMs
  • In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines
  • NAMs in the Environmental toxicity / Green deal
  • Mixtures and biomonitoring
  • In vitro COVID-19 research/lung and cardiovascular models
  • In vitro methods for safety assessment of medical devices
  • GIVIMP, GCMP and GLP
  • Other

Scientific Programme – Session details

The programme is still subject to change – the final version will be available on October 1st

Monday, November 21st, 2022

09:00-13:00: Pre-conference workshopBridging across methods in the biosciences (BeAMs): the opportunity of COVID-19 (organised with JRC)
Chairs: Dr Annamaria Carusi & Dr Sofia Batista Leite

13:00-14:00: Lunch break

14:00-14:20: Opening of ESTIV 2022 Congress
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia – ESTIV President) & Dr João Barroso ( JRC, Ispra Italy -ESTIV Vice-president)

14:20-15:10: Keynote lecture by Dr Timothy Allen (University of Cambridge, Cambridge, UK / Ladder Therapeutics, Toronto, Canada)
Use of Artificial Intelligence and Machine Learning in the Chemical Risk Assessment
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia – ESTIV President) & Dr João Barroso (JRC, Ispra Italy -ESTIV Vice-president)

15:10-15:15: ESTIV Early Scientific Career Award ceremony 2020/2022
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia – ESTIV President) & Dr João Barroso (JRC, Ispra Italy -ESTIV Vice-president)

15:15-16:00: BEMF Award ceremony and BEMA Lecture
Chairs: Prof. Stina Oredssson (Björn Ekwall Memorial Foundation, Sweden)

16:00-16:30: Coffee break, visiting exhibition area & poster viewing

16:30-18:30: Session 1 – Bio-engineering, stem cells and disease models
Chairs: Prof. Peter Loskill (University of Tübingen, Germany) & D. João Barroso (JRC, Ispra, Italy – ESTIV Vice-president)

  • Peter Loskill – Recapitulating Complex Human Tissues using Organ-on-chip and Organoid Technologies – (Invited lecture)
  • Lena Smirnova – iPSC-derived Brain Organoids as versatile research tool for Developmental Neurotoxicity and Neurological disorders
  • Alec Salminen – Evaluation of 3D-Bioprinted Human Skin Equivalents for In Vitro Permeation Testing
  • Pau Sancho-Bru- iPSC-derived hepatic stellate cells for in vitro fibrosis modelling
  • Aafke Janssen – Transport of per-and Polyfluoralkyl substances (PFAS) across human induced pluripotent stem cell (HIPSC) derived intestinal epithelial cells in comparison with human primary intestinal epithelial calls and Caco-2 cells


19:00-20:30: Welcome reception & poster session


Tuesday, November 22nd, 2022

8:30-10:30: Session 2a – Models, biomarkers and assays for endocrine disruption and developmental toxicity
Chairs: Dr Thomas Knudsen (US EPA, Durman, USA) & Prof. Arno Gutleb (LIST, Luxembourg, Luxembourg)

  • Ingrid Langezaal – Upcoming validated mechanistic in vitro methods for the identification of thyroid disruptors.
  • Andrew Tindall – Interlaboratory OECD Validation of the Rapid Androgen Disruption Adverse outcome Reporter (RADAR) assay
  • Nina Hambruch – Validation of a New Approach Method (NAM) testing DIO1 inhibition using a human microsome-based, colorimetric assay
  • Erica Buoso – Immunological implications of Endocrine Disrupting Chemicals (EDCs): RACK1 as a bridge between the endocrine and the immune systems
  • Predrag Kukic – Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing

8:30-10:30: Session 2b Challenges in cosmetics safety

Chairs: Dr Nathalie Alépée (L’Oréal, Paris, France) & Dr Erwin Van Vliet (Houten, Utrecht, Netherlands)

  • Jay Ingram – Global Regulatory Landscape for Cosmetics – Challenges and Opportunities in Utilising NAMs
  • Els Adriaens – Overview of New Approach Methodologies for eye hazard identification according to UN GHS
  • Nathalie Alépée – Application of an updated Next Generation Risk Assessment (NGRA) framework for skin allergy: a case study for Diethanolamine
  • Véronique Poulsen – New challenges for environmental safety of cosmeticscccccccssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssssss ssssssssssssssssssssssssssssssssssssssssssssssssssssssssss

10:30-11:00: Coffee break, visiting exhibition area & poster viewing


11:00-13:00: Session 3a – Models, biomarkers and assays for systemic and immune toxicity
Chairs: Prof. Emanuela Corsini (Universita degli Studi di Milano, Milan, Italy) & Dr Jochem Louisse (Wageningen University, Wageningen, The Netherlands)

  • Emanuela Corsini New approach methodologies in immunotoxicology with a focus on immunosuppression (Invited lecture)
  • Herve Groux – In vitro evaluation of both skin irritation and sensitization hazard of mixtures and finished products using the SENS-IS assay.
  • Laura Suter-Dick – Multicellular, liver microtissues reliably depict key events of the liver fibrosis AOP
  • Birgitte Lindeman – Immunotoxicity of crystalline silica particles: in vitro screening models and use of high-dimensional immune cell profiling
  • Sabina Burla – A 3D Alveolar In Vitro Test System for the Prediction of Chemical Respiratory Sensitizers
  • Andy Forreryd – In vitro assessment of skin sensitizing potential of process-related impurities in polymeric materials during product development.

11:00-13:00: Session 3b – Organ-on-a-chip & Microphysiology systems
Chairs: Dr Sofia Batista Leite (JRC, Ispra, Italy) & Dr Pau Sancho-Bru (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain)

  • Silvia Scaglione – A new immunocompetent OOC platform for culturing 3D human tissues with capillary flow-driven immune cells and investigating their cross-talk
  • Julia Boos – Integration of human-stem-cell-based embryoid bodies into a microfluidic multi-tissue platform for systemic embryotoxicity testing
  • Ilka Maschmeyer – Multi-Organ-Chip Technologies: The effect of application route on the metabolism
  • Aude Rapet – A breathing lung-on-chip model: an advanced in-vitro tool for drug testing and toxicology
  • Leopold Koenig – A microfluidic bone marrow chip for the safety profiling of complex large molecules in pre-clinical drug development
  • Roberta Visone – A human beating heart on chip for online screening of drug cardiotoxicity

13:00-14:00: Lunch break, visiting exhibition area & poster viewing

ILSI Europe | LinkedIn

13:00-14:00: ILSI/ESTIV- sponsored lunch session: Application of non-animal methods and concepts in food risk assessment
Chairs: Dr Isabelle Guelinckx (ILSI Europe, Belgium) & Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia)


14:00-16:00: Session 4a – Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning
Chairs: Prof. Olivier Taboureau (University Paris Diderot, Paris, France) & Dr Tim Allen (Ladder Therapeutics, Toronto, Canada)

  • Thomas Knudsen – Computational systems models for human-predictive developmental toxicity (Invited lecture)
  • Thomas HartungInvited lecture (topic to be announced)
  • Ignacio Tripodi – Turning AOPs into testable hypotheses with natural language processing and tissue-specific knowledge graphs
  • Prachi Pradeep – Integrating in vitro and in silico data for screening and characterization of tattoo pigments for human health risk assessment
  • Donatella Carpi – Modelling in vitro time-concentration response of gene expression to chemical exposure

14:00-16:00: Session 4b – Local toxicity testing (safety and efficacy)
Chairs: Dr Montserrat Mitjans (Universitat de Barcelona, Barcelona, Spain) & Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia)

  • Els Adriaens – A new OECD guideline based on Defined Approaches for Eye Hazard Assessment of non-surfactant liquids combining Physicochemical Properties and OECD-approved Test Methods
  • Manon Barthe – Modeling skin inflammation using 2D and 3D in itro models
  • Elena Grasselli – In vitro investigation of aluminum bioavailability after exposure of oral care products
  • Eric Andres – Integrative evaluation strategy for skin sensitization : the mixtures challenge
  • Renato Ivan de Ávila – Application of a next-generation risk assessment framework for skin sensitisation using new approach methodologies (NAMs): geraniol case study


16:00-16:30: Coffee break, visiting exhibition area & poster viewing


16:30-17:30: Early Stage Researcher Session 1
Chairs: Dr Erwin van Vliet (Houten, Utrecht, Netherlands) & Dr Pau Sancho-Bru (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain)

  • Méryl Roudaut – A single procedure to generate functional hiPSCs-derived liver organoids – Towards an innovative tools suitable for drug screening
  • Jördis Klose – In vitro screening for developmental neurotoxicity of flame retardants using a 3D human primary neural progenitor cell assay: a case study
  • Yanying Ma – Predicting developmental toxicity of pyrethroid insecticides in vitro using human-induced pluripotent stem cells
  • Rima Souki – Characterization of extracellular vesicles released by peripheral blood mononuclear cells exposed to polycyclic aromatic hydrocarbons and study of their interaction with endothelial cells
  • Michelle Jäschke – Towards a personalized kidney-on-a-chip derived from induced pluripotent stem cells

17:30-18:30: Early Stage Researcher Session 2
Chairs: Dr Montserrat Mitjans (Universitat de Barcelona, Barcelona, Spain) & Dr. Marketa Dvořáková (NIPH Prague, Prague, Czech republic)

  • Heart Avner Ehrlich – The Electro-Mitochondrial Coupling of a Microphysiological Human
  • Ahmet Kati – Affinity prediction between cosmetic ingredients and CD54/CD86 receptors by molecular docking: A novel approach to predict skin sensitisation potential
  • Filipa Leal – Electrospun scaffold-based approaches for toxicological screening in skin, pulmonary, and intestinal epithelial tissue
  • Zachary Sitte – Developing a method to incorporate laminar flow into scaffold-based 3D cell cultures for more physiologically relevant nutrient and drug delivery.
  • Marie Frerejacques – Kidney organoids for toxicology: application to the development of Adverse Outcome Pathway (AOP) study of nephrotoxicity induced by uranium

16:30-17:30: Sponsored session I
Chairs: Erin Hill (IIVS, Gaithersburg, MD, USA) & Dr Clive Roper (Roper Toxcilogy Consulting Limited, UK)

  • Angela Hvitved – Research support to replace animal models: the Alternatives Research & Development Foundation (ARDF) Annual Open grant program

17:30-18:30: Sponsored session II
Chairs: Erin Hill (IIVS, Gaithersburg, MD, USA) & Dr Clive Roper (Roper Toxicology Consulting Limited, UK)

  • t.b.c


18:30 – 19:00 Career development session


19:30-… Wine reception in the poster area


Wednesday, November 23th, 2022

08:30-10:30: Session 5a – Toxicokinetics and in vitroin vivo extrapolation
Chairs: Dr Nicole Kleinstreuer (NICEATM, Durham, USA) & Dr Jochem Louisse (Wageningen University, Wageningen, The Netherlands)

  • Nicole Kleinstreuer – An Open, Accessible Interface for Contextualizing Chemical Effects (Invited lecture)
  • Andreas Schepky – Crucial role of Toxicokinetics and ADME methods in the application of Next-generation Risk Assessment
  • Ans Punt – Generic PBK models based on in vitro and in silico input data: How to gain trust in the results?
  • Sophie Werner – Use of a 3d-in vitro model for the assessment of liver metabolism related to neurotoxicity of occupationally relevant chemicals
  • Norman Nowak – Design and Application of a Physiologically Based Kinetic (PBK) Model for Uptake of Gases and Vapours
  • Julia Huchthausen – High-Throughput Assessment of the Abiotic Stability of Test Chemicals in In Vitro Bioassays

08:30-10:30: Session 5bIn vitro systems to assess respiratory toxicity
Chairs: Erin Hill (IIVS, Gaithersburg, MD, USA) & Dr Clive Roper (Roper Toxcilogy Consulting Limited, UK)

  • Andreas Stucki – Evaluating human cell-based in vitro systems to assess respiratory toxicity – is more complex better?
  • Artur Christian Garcia da Silva – Development and characterization of a decellularized bronchial scaffold for application in physiologically relevant 3D airway models reconstruction
  • Victoria Hutter – The application of alveolar macrophage responses for respiratory safety assessment
  • Jan Markus – Prediction of acute respiratory toxicity of volatile liquids using physiologically relevant in vitro inhalation model
  • Margaux Cochard – Impact of airborne particulate matter from port, industrial and urban areas on oxidative and inflammatory responses on lung cells.

10:30-11:00: Coffee break, visiting exhibition area & poster viewing


11:00-13:00: Session 6a – In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines
Chairs: Dr Michael Rothe (Hannover Medical School, Hannover, Germany) & Prof. Anne Marie Vinggaard (Technical University of Denmark, Denmark)

  • Michael RotheIn vitro assays to predict retroviral vector-induced genotoxicity (Invited lecture)
  • Jean-Pierre Valentin – State-of-the-Art in Secondary Pharmacology and its Impact on the Safety of New Medicines
  • Terry Riss – Exploiting Real-Time Assays to Multiplex Orthogonal Methods and Determine Mechanism of Action During In Vitro Safety Testing
  • Bettina Seeger – Botulinum neurotoxin potency testing in vitro – Motor neurons differentiated from human-induced pluripotent stem cells serve as highly suitable target cells
  • Zachary Sitte – Supported Gel Slabs: Decreasing the barrier of entry for use of 3D cell cultures in the drug discovery workflow
  • Jean-Pierre Valentin – Mechanistic investigations and early de-risking of QRS complex widening to improve cardiac safety profile of novel anti-malarials

11:00-13:00: Session 6b Knowledge sharing and education
Chairs: Prof. Pilar Vinardell (Universitat Barcelona, Barcelona, Spain) & Erin Hill (IIVS, Gaithersburg, MD, USA)

  • Pierre Deceuninck – The science of sharing knowledge about models and methods
  • Kirk Leech – Animal Research: Time to Talk!
  • João Barroso – Scientific Validity of Non-Animal-Derived Antibodies
  • Tilo Weber -Animals in the (Petri) Dish: Towards a Truly Animal-free Laboratory
  • Catharine Krebs – Outcomes of a workshop to address animal methods bias in scientific publishing
  • Catherine Willett – A Course on Animal-Free Risk Assessment of Cosmetics and Cosmetic Ingredients

13:00-14:00: Lunch break, visiting exhibition area & poster viewing

13:00-14:00: JSAAE – sponsored session – Asian progress in 3Rs:
3rd Asian congress and KSAAE updates

Chairs: Dr Yasunari Kanda (National Institute of Health Sciences, Japan) & Dr Kwang-Mahn Kim (Yonsei University, South Korea)


14:00-15:00: Debate session (for and against): Use of Artificial Intelligence and Machine Learning in Chemical Risk Assessment
Chair: Dr Joao Barroso (JRC, Ispra, Italy)

Invited Debaters: Dr Timothy Allen (Ladder Therapeutics, Toronto, Canada) and Dr Nicole Kleinstreuer (NICEATM, Durham, USA)


15:00-16:00: Poster teaser session: Flash presentations of selected posters
(selected posters will be announced in September)


16:00-16:30: Coffee break, visiting exhibition area & poster viewing (until 18:30)


16:30-18:30: ESTIV General Assembly
(ESTIV members)


19:30- … Congress gala dinner & social evening


Thursday, November 24th, 2022

08:30-10:30: Session 7a – Developmental Neurotoxicity (DNT)
Chairs: Dr. Ellen Fritsche & Clive Roper (Roper Toxcilogy Consulting Limited, UK)

  • Ellen Fritsche – Developmental neurotoxicity (DNT) as a case study on how to assemble an in vitro testing battery for a complex regulatory in vivo endpoint
  • Eliska Kuchovska – First steps for creating an ontology for cognitive function defects for regulatory application
  • Maxime Culot – Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing
  • Elisabet Teixido – Comparative developmental neurotoxicity of NSAIDs in the zebrafish
  • Marta Barenys – an adverse outcome pathway (AOP) based approach to identify changes in prenatal brain programming
  • Laure-Alix Clerbaux – effects of spike protein and toxin-like peptides found in covid-19 patients on human 3d neuronal/glial model undergoing differentiation: possible sars-cov-2 implications for brain development

08:30-10:30: Session 7b – Implementation of NAMs into regulatory frameworks – establishing scientific confidence, development of standards and good practices
Chairs: Dr. Marketa Dvořáková (NIPH Prague, Prague, Czech republic) &Dr. Jochem Louisse (Wageningen University, Wageningen, The Netherlands)

  • Sandra Coecke – Method developers are key players ensuring in-house reproducibility and relevance of in vitro methods paving the way for regulatory acceptance
  • Amanda Ulrey – Good In Vitro Method Practices Certification: A Roadmap for Implementation and Harmonization
  • Maren Hülsemann – Quality enhancing measures in organ model research
  • Annelies Noorlander – towards standardization of testing methods for comparative in vitro metabolism (CIVM) studies


10:30-11:00: Coffee break


11:00-12:40: Session 8a – In vitro methods for safety assessment of medical devices
Chairs: Dr. Christian Pellevoisin (MatTek Life Sciences, France) & Dr. Helena Kandarova (CEM SAS, Bratislava, Slovakia)

  • Christian Pellevoisin – ISO 10993 SERIES: Added value of 3D models for Biocompatibility testing of medical devices (Invited lecture)
  • Stefan Weissensteiner – Why in-vivo methods for the assessment of sensitization might be outdated in the near future
  • Cristina Garcia-Bonillo – hemocompatibility of bacteriophobic coated catheters
  • Marisa Meloni – Biocompatibility of medical devices: eye irritation of preserved and unpreserved eye drops on HCE model
  • Hervé Groux – Measurement of metal sensitizer potency with the SENS-IS assay. Application to Medical devices

11:00-12:40: Session 8b In vitro COVID-19 research / Lung and cardiovascular models
Chairs: Prof. Arno Gutleb (LIST, Luxembourg, Luxembourg) & Dr. Yasunari Kanda (National Institute of Health Sciences, Japan)

  • Sandra Coecke – Knowledge from Human Relevant Cell, Tissue and Mathematics-based Methods as Key Tools for Understanding COVID-19 Dynamics, Kinetics, Symptoms, Risk Factors and Non-conventional Treatments
  • Samuel Constant – 3D Human airway epithelial models to study SARS-CoV-2 pathogenesis and to discover antivirals
  • Axelle Cooreman – Effects of drugs formerly repurposed for COVID-19 treatment on connexin43 hemichannels and pannexin1 channels
  • Chloé Chivé – Use of a human bronchial epithelium model to assess the impact of PM2.5 exposure on the severity of viral infections
  • Avner Ehrlich – Metabolic Regulation of SARS-CoV-2 Infection

12:40-13:30: Congress closing ceremony
Chairs: Dr. Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr. João Barroso (JRC, Ispra Italy)


POST-CONFERENCE ACTIVITIES


Friday, November 25th, 2022

Scientific Programme – tabular overview

TimeMonday
21.Nov 2022
Tuesday
22.Nov 2022
Wednesday
23.Nov 2022
Thursday
24.Nov 2022
Friday
25.Nov 2022
08:30-10:30Pre-conference workshopBridging across methods in the biosciences (BeAMs): the opportunity of COVID-19 (organised with JRC) Session 2a – Models, biomarkers and assays for endocrine disruption and developmental toxicity

Session 2b Challenges in cosmetic regulations
Session 5a – Toxicokinetics and in vitroin vivo extrapolation

Session 5b – Animal product free NAMs
Session 7a – Mixtures risk assessment in the past and the future

Session 7b – Implementation of NAMs into regulatory frameworks – establishing scientific confidence, development of standards and good practices

Post-conference workshop with EPISKIN Academy
***
ASPIS Cluster meeting
10:30-11:00Coffee break, visiting exhibition area & poster viewing
Coffee break, visiting exhibition area & poster viewing
Coffee break, visiting exhibition area & poster viewing
11:00-13:00 Pre-conference workshopBridging across methods in the biosciences (BeAMs): the opportunity of COVID-19 (organised with JRC) Session 3a – Models, biomarkers and assys for systemic and immune toxicity

Session 3b – Organ-on-chip models

Session 6a In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines

Session 6b – Knowledge sharing and education – how to implement the knowledge on NAMs and 3Rs into education systems
Session 8a – In vitro methods for safety assessment of medical devices

Session 8b – In vitro COVID-19 research / Lung and cardiovascular models
Post-conference workshop with EPISKIN Academy
***
ASPIS Cluster meeting
13:00-14:00Lunch break, visiting exhibition area & poster viewing Lunch break, visiting exhibition area & poster viewing

ILSI/ESTIV- sponsored lunch session: Application of non-animal methods and concepts in food risk assessment
Lunch break, visiting exhibition area & poster viewing

JSAAE – sponsored lunch session – Asian progress in 3Rs:
3rd Asian congress and KSAAE updates
Congress closing ceremony
14:00-16:00Opening of ESTIV2022

Keynote lecture

ESTIV Early Scientific Career Award ceremony 2020/2022

BEMF Award ceremony and BEMA Lecture
Session 4a – Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning

Session 4b – Local toxicity testing (safety and efficacy)
Debate session (for and against): Use of Artificial Intelligence and Machine Learning in Chemical Risk Assessment (Debate session I) Post-conference workshop with EPISKIN Academy
***
ASPIS Cluster meeting
ASPIS Cluster meeting
16:00-16:30Coffee break, visiting exhibition area & poster viewingCoffee break, visiting exhibition area & poster viewingCoffee break, visiting exhibition area & poster viewing Coffee break
16:30-18:30Session 1 – Bio-engineering, stem cells and disease modelsEarly Stage Researcher Sessions I & II

Sponsored sessions I & II
Early Stage Researcher Poster session / Early career session

ESTIV General Assembly
Post-conference workshop with EPISKIN Academy
***
ASPIS Cluster meeting
19:30-….Welcome reception & poster sessionCongress gala dinner & social evening