Accepted Posters

Instructions for Poster Presenters

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Poster print service:

If you would like to use the poster printing service, please find below the correct procedure.
1. Send an email to Lidia Anta via bcncongress@bcncongress.com with a PDF attachment of the poster.
2. Make sure that the date of the congress and the name of the congress are clearly mentioned in the e-mail.
3. Clearly state in the e-mail the name that should be on the poster tube. This is the person who will collect the poster.
3. The poster can be picked up at the registration desk during the congress days.

The cost is € 74,25 and should be paid after ordering the poster print.
The poster will be printed on A0 size and weigh 150 grams.

The deadline for this service is 11th November 2022.

SESSION

1. Bio-engineering, stem cells and disease models
2a. Models, biomarkers and assays for endocrine disruption and developmental toxicity 
2b. Challenges in cosmetics safety 
3a. Models, biomarkers and assays for systemic and immune toxicity 
3b. Microphysiological Systems  
4a. Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning
5a. Toxicokinetics and in vitro – in vivo extrapolation
5b. In vitro systems to assess respiratory toxicity
6a. In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines
6b. Knowledge sharing and education
7a. Developmental Neurotoxicity (DNT)
7b. Implementation of NAMs into regulatory frameworks
8a. In vitro methods for safety assessment of medical devices
8b. In vitro COVID-19 research / Lung and cardiovascular models
9. Models and methods
10. Nanoparticles research in vitro   

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1. Bio-engineering, stem cells and disease models 

P-1-1

The effect of methylmercury chloride on three germ layer formation during hiPSC-derived Embryoid Bodies development

Justyna Augustyniak¹, Hanna Kozlowska², Agnieszka Stasinska¹, Leonora Buzanska^P1
1 Department of Stem Cells Bioengineering, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
² Laboratory of Advanced Microscopy Techniques, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
^P Presenting author

P-1-2

Preliminary evaluation of extracted collagen from food fish-processing side streams as an active ingredient for cosmetic application.

Lorenzo Dondero^P1, Giulia De Negri Atanasio¹, Federica Robino², Anastasiia Kharina², Micaela Tiso³, Francesca Rispo¹, Giorgia Allaria¹, Francesca Tardanico¹, Federica Turrini⁴, Federica Grasso⁴, Valentina Orlandi⁴, Matteo Zanotti Russo², Raffaella Boggia⁴, Elena Grasselli^1
1  Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
² ANGEL CONSULTING S.a.s. , Italy
³ MICAMO Spin-Off Department of Earth Sciences, University of Genoa, Genova, Italy
⁴ Department of Pharmacy, University of Genoa, Genova, Italy
^P Presenting author

P-1-3

An innovative and robust strategy to generate hepatocyte-like cells from individual patients to investigate idiosyncratic hepatotoxicity of drugs

GUILLEM GARCIA LLORENS^P1,2, TERESA MARTÍNEZ SENA¹, JOSE VICENTE CASTELL RIPOLL^1,2,3, ROQUE BORT MARTI^1,3
1 Experimental Hepatology Research Unit, Instituto de Investigación Sanitaria La Fe
²  Biochemistry and Molecular Biology Department, Universidad de Valencia, Valencia, Spain.
³ CIBEREHD
^P Presenting author

P-1-4

Human peripheral neurons with enhanced nociceptor features for the study of pain-related dysfunctions

Anna-Katharina Holzer^P1, Christiaan Karreman¹, Ilinca Suciu¹, Harald Wohlfarth¹, Marcel Leist^1
1 In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation at the University of Konstanz, Germany
^P Presenting author

P-1-5

Development of in vitro cardiotoxicity assessment using human iPS cell technology

Yasunari Kanda^P1, Sae Hayashi¹, Ayano Satsuka^1
1 National Institute of Health Sciences (NIHS) Japan
^P Presenting author

P-1-6

Stem cell toxicity is detected by cell internal indicator, SERPINB2

Seong-Kwan Kim^P1,2, Se-Ra Park^1,2, Soo-Rim Kim^1,2, In-Sun Hong^1,2
1 Laboratory of stem cell research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.
² Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 406-840, Republic of Korea.
^P Presenting author

P-1-7

Establishment of an in vitro rabbit neurosphere model  to evaluate neurodevelopmental adverse effects induced by Intra-uterine growth restriction (IUGR) and to test future therapies

Britta Anna Kühne^P1,2, Paula Vázquez^1,2, Carla Loreiro², Fatima Crispi², Eduard Gratacós², Jesús Gómez-Catalán¹, Ellen  Fritsche³, Miriam Illa², Marta Barenys^1,2
1 GRET, INSA‐UB and Toxicology Unit, Pharmacology and Therapeutical Chemistry Department, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
² BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Fetal i+D Fetal Medicine Research Center, IDIBAPS, Barcelona, Spain.
³ IUF – Leibniz Research Institute for Environmental Medicine. Auf’m Hennekamp 50, 40225 Düsseldorf, Germany.
^P Presenting author

P-1-8

Generation of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes using the Aurora Kinase Inhibitor ZM447439

Su-Jin Lee^P1, Hyang-Ae Lee^1
1 Korea Institute of Toxicology
^P Presenting author

P-1-9

Mechanism of the Cyclic Stretch Induced Maturation of the Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

Hyang-Ae Lee^P1, Su-Jin Lee¹, Hyeon-A Kim^1
1 Korea Institute of Toxicology
^P Presenting author

P-1-10

Cellular Model of Parkinson`s Disease for Safety Testing of Selenium-Based Nanodelivery System

Ivan Mamić^P1, Maja Beus², Nikolina Kalčec², Nikolina Peranić², Petra Turčić¹, Ivana Vinković Vrček^2
1 Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, Zagreb, Croatia
² Institute for Medical Research and Occupational Health, Ksaverska cesta 2, Zagreb, Croatia
^P Presenting author

P-1-11

Study the toxicity effect of Cycloporin A on angiogenesis progress of endothelial cells derived from induced pluripotent stem cells

Zahra Mazidi^P1, Matthias  Wieser¹, Regina  Grillari², Johannes Grillari^3
1 Evercyte GmbH
² Evercyte GmbH, Correspondence author
³ Ludwig Boltzmann Institiute, Evecyte GbmH, Correspondence Author
^P Presenting author

P-1-12

Discovery of a novel function, immune-modulatory factor CSF-2, improves the therapeutic effect of stem cells from cell damage

Se-Ra Park^P1,2, Seong-Kwan  Kim^1,2, Soo-Rim Kim^1,2, In-Sun  Hong^1,2
1 Laboratory of stem cell research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.
² Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 406-840, Republic of Korea.
^P Presenting author

P-1-13

Studying melanoma progression on a commensal 3D-skin model

Aline Rosin^P1, Maya Kissner¹, Tewes Tralau², Lisa  Lemoine^1
1 German Federal Institute for Risk Assessment Department Pesticides Safety, Junior Research Group Skin Microbiome
² German Federal Institute for Risk Assessment Department Pesticides Safety
^P Presenting author

P-1-14

A novel in vitro 3D model of chronic kidney disease (CKD) in the proximal tubule for drug development and safety.

Elena Tasinato^P1,2, Kathryn Garner², Lyle Armstrong^1,2, Colin D A Brown^2
1 Newcastle University
² Newcells Biotech
^P Presenting author

P-1-15

ACCURATE EVALUATION OF DRUG METABOLISM BY ENHANCED HEPATOCYTE FUNCTIONS IN A NEW OXYGEN-PERMEABLE PLATE WITH LOW DRUG ADSORPTION

Yasuyuki Sakai^P1, Masaki Nishikawa¹, Hiroyasu Itoh¹, Fumiya Tokito¹, Mathieu Danoy¹, Takumi Kawanishi², Hiroshi Arakawa², Yukio Kato², Tomoaki Matsugi³, Jingjing Yang³, Katsuhiro Esashika³, Toru Sumita^3
1 University of Tokyo
² Kanazawa University
³ Mitsui Chemicals, Inc.
^P Presenting author

P-1-16

3D multi cell-type liver organoids as an alternative NAFLD model for drug safety assessment

Ferron Pierre-Jean^P1
1 INSERM – U1241
^P Presenting author

P-1-17

A novel in vitro iPSC-based cardiac organoid model for personalized medicine.

Rosaria Santoro^P1, Luca Piacentini¹, Chiara Vavassori¹, Maura Brioschi¹, Cristina Banfi¹, Elena  Donetti², Patrizia Benzoni², Andrea Barbuti², Giulio Pompilio^1
1 Centro Cardiologico Monzino IRCCS
² University of Milan
^P Presenting author

P-1-18

Advanced in vitro model for drug induced kidney injury assessment – generation of kidney organoid for safety assessment purposes

Lukas Wijaya¹, Sylvia le Dévédec¹, Bob van de Water<sup>1

1</sup>Leiden Academic Centre for Drug Research

P-1-19

NEXT GENERATION TARGET ORGAN TOXICITY RISK ASSESSMENT: ENDOGENOUSLY TAGGED HUMAN STEM CELL REPORTERS FOR HIGH-CONTENT SCREENING OF OXIDATIVE STRESS RESPONSE

Tamara Danilyuk<sup>1

1</sup>Leiden University

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2a. Models, biomarkers and assays for endocrine disruption and developmental toxicity 

P-2a-1

Chlorpyrifos impairs immortalized hypothalamic murine GnRH neurons at human relevant exposure levels

Gabriele Lori^1,2, Maria Luisa Casella³, Antonella Tinari¹, Sabrina Tait^P1
1 Center for Gender-Specific medicine, Istituto Superiore di Sanità
² Science Department, Università Degli Studi di Roma Tre
³ Core Facilities, Istituto Superiore di Sanità
^P Presenting author

P-2a-2

Evaluation of the local tolerance of flagellin aerosol therapy (FLAMOD) on primary human cell-based 3D in vitro nasal, bronchial, small-airway and alveolar models

Jean-Claude Sirard¹, Itziar Sanjuan¹, Charlotte Green-Jensen², Nathalie Heuze Vourc’h³, Edouard Sage ⁴, Cindia Ferreira^P5, Samuel Constant^5
1 Institut Pasteur de Lille – Inserm, France
² Statens Serum Institut
³ Université de Tours, France
⁴ Hopital Foch, France
⁵ Epithelix
^P Presenting author

P-2a-3

Investigation on the reproducibility of the DIO1 inhibition in vitro method based on human liver microsomes

Andreas-Georg Weber¹, Barbara Birk¹, Hans-Albrecht Huener¹, Kostja Renko², Sandra Coecke^P3, Steffen Schneider¹, Bennard Van Ravenzwaay¹, Robert Landsiedel^3
1 BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
² 2Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
³ European Commission, Joint Research Centre (JRC), Ispra, Italy
^P Presenting author

P-2a-4

A closer look at the evaluation criteria of the H295R In vitro Steroidogenesis Assay test guideline

Caroline Gomes¹, Claudia Ruelker¹, Nina Hambruch^P1, Tilmann Walk², Michael Herold², Naveed  Honarvar¹, Hennicke Kamp², Dorothee Funk-Weyer¹, Robert Landsiedel^1
1 BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
² BASF Metabolome Solutions GmbH, Berlin, Germany
^P Presenting author

P-2a-5

LC-MS based analysis of substance-induced displacement of thyroid hormone from its serum binding protein

Andreas Weber¹, Lars-Henrik Koeppl¹, Melanie Weißenfeld¹, Nina Hambruch^P1, Barbara Birk¹, Eric Fabian¹, Steffen Schneider¹, Stephanie Melching-Kollmuss², Dorothee Funk-Weyer¹, Robert Landsiedel^1
1 BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
² BASF SE, Agriculture Solutions, Global Toxicology, Limburgerhof, Germany
^P Presenting author

P-2a-6

Impact of interference with retinoid signaling on in vitro differentiation in human neural stem cell-based model

Barbara  Kubickova ¹, Sarka Martinkova¹, Ondrej Brozman¹, Klara Hilscherova^P1
1 RECETOX, Faculty of Science, Masaryk University
^P Presenting author

P-2a-7

In Vitro pharmacologic profiling For Cosmetic Chemical Systemic Toxicity Safety Testing: A case study on Homosalate

Matthew Burbank^P1, Nicola Jane Hewitt², Gerry Kenna², Mareike Boettcher³, Catherine Mahony⁴, Johanna Ebmeyer³, Duncan Armstrong⁵, Audrey Noel-Voisin⁶, Anne Riu⁷, Gladys Ouedraogo^7
1 L’Oréal Research and Innovation, , Aulnay-sous-Bois, France
² Cosmetics Europe, Brussels, Belgium
³ Beiersdorf AG Hamburg, Germany
⁴ Procter & Gamble Technical Centres LTD, Reading, UK
⁵ Duncan Armstrong, Armstrong Pharmacology Ltd., Macclesfield, UK
⁶ L’Oréal Research and Innovation, Clichy, France
⁷ L’Oréal Research and Innovation, Aulnay-sous-Bois, France
^P Presenting author

P-2a-8

Test Guideline No. 248 (XETA): a new OCDE approved alternative method for the identification of thyroid active chemicals

David Du Pasquier^P1, Gregory Lemkine^1
1 Laboratoire Watchfrog
^P Presenting author

P-2a-9

Relevant impact on the endocrine activity potential by modification of classical in vitro transactivation assays – exemplary case studies with two UV filters

Sylvie  Emery^P1, Guillaume Lereaux¹, Sébastien  Grégoire¹, Matthew Burbank¹, Nicola Jane Hewitt², Audrey Noel-Voisin³, Dagmar Bury³, Gladys Ouedraogo¹, Anne Riu^1
1 L’Oréal, Research and Innovation, Aulnay-sous-Bois, France
² Cosmetics Europe, Brussels, Belgium
³ L’Oréal Research and Innovation, Clichy, France
^P Presenting author

P-2a-10

INCORPORATING A METABOLIZING SYSTEM AND TOPICAL APPLICATION TO IMPROVE THE VALUE OF IN VITRO ENDOCRINE DISRUPTION ASSAYS

Sylvie EMERY^P1, Guilaume  LEREAUX¹, Matthew Burbank¹, Sébastien GREGOIRE¹, Dagmar  BURY², Véronique  POULSEN², Anne RIU^3
1 L’Oréal, Research & Innovation, Aulnay-sous-Bois, France
² L’Oréal Research and Innovation, Clichy, France.
³ L’Oréal Research and Innovation, Aulnay-sous-Bois, France
^P Presenting author

P-2a-11

The agonistic bioanalytical equivalent concentration: A novel tool for assessing the endocrine activity of environmental mixtures

Martin Ezechiáš^P1
1 Institute of Microbiology of the Czech Academy of Sciences
^P Presenting author

P-2a-12

ENDOCRINE DISRUPTION – BREAKING FREE FROM IN VIVO TESTING ORTHODOXY

Erik Prochazka^P1, Emma Grange^1
1 Cruelty Free Europe
^P Presenting author

P-2a-13

PERFORMANCE LIMITATION OF OECD TEST NO. 455 ESTROGEN RECEPTOR TRANSACTIVATION ASSAY CLASSIFICATION CRITERIA USING VM7LUC4E2 CELL LINE.

Theo Le Godec^P1, Poornima Paramasivan¹, Michael McMahon², Matilda  Bingham^1
1 Concept Life Sciences
² Penman Consulting
^P Presenting author

P-2a-14

A metabolomics approach to investigate in vitro the hepatotoxicity of drugs and the mechanisms so far involved

Teresa Martinez-Sena^1,2, Erika Moro¹, Marta Moreno^P1, Jose V. Castell^1,3
1 Experimental Hepatology, IISLAFE
² Analytical Chemistry, University of Valencia
³ Departament of Biochemistry and Molecular Biology
^P Presenting author

P-2a-15

Validation of Endocrine Disrupter Assays at EURL ECVAM

Anne  Milcamps^P1, Elise  Grignard¹, Ingrid Langezaal¹, Roman Liska¹, Camilla Bernasconi¹, Gerard Bowe¹, Tom Cole¹, Sandra Coecke¹, Francesca Pistollato¹, Valerie Zuang¹, Sharon Munn^1
1 European Commission
^P Presenting author

P-2a-16

THE ADIPOGENESIS MODEL OF HUMAN MESENCHYMAL STEM CELLS FOR THE DETERMINATION OF OBESOGENIC POTENTIALS OF SUNSCREENS

Minsoo Noh^P1, Sungjin Ahn¹, Seungchan An¹, In Guk Park¹, Seok Young Hwang¹, Junpyo Gong^1
1 College of Pharmacy, Seoul National University
^P Presenting author

P-2a-17

INCREASING THE NUMBER OF AVAILABLE METHODS FOR THE DETECTION OF ENDOCRINE DISRUPTORS BEYOND EATS

Andrea RIVERO-ARZE^P1, Elise GRIGNARD¹, Philippe HUBERT^1
1 PEPPER – Paris (FR)
^P Presenting author

P-2a-18

EVALUATION OF THE CYTOTOXICITY OF TETRAHYDROCANNABINOL,CANNABINOL AND CANNABIDIOL IN PRECURSOR CELLS OF THE GLIA

Rene  Rocha^P1, Javier  Figueroa¹, Diego Diaz¹, Boris Duffau¹, Ivan  Triviño^1
1 Instituto de Salud Publica de Chile
^P Presenting author

P-2a-19

Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test

Elisabet Teixido^P1, Odile Kerkhof^2,3, Nils Klüver², Tobias R Kiessling⁴, Stefan Scholz^2
1 GRET-Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.
² Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraβe 15, 04318, Leipzig, Germany.
³ French agency for food, environmental and occupational health and safety, Anses, France.
⁴ Scientific Software Solutions, 04275, Leipzig, Germany.
^P Presenting author

P-2a-20

Study of Endocrine disruptors-related lipid and carbohydrate metabolism disorders in human hepatocytes

Charbel Touma^P1, Kevin BERNAL², Frederic  EZAN ¹, Sophie  ROSE ¹, Antoine LEGRAND¹, Valentine BROURAD¹, Béatrice LE-GRAND², Corinne CHOULY¹, Dominique LAGADIC¹, Etienne BLANC², Sophie LANGOUËT^1
1 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, 35000 Rennes, France
² Inserm UMR-S 1124, T3S, Université Paris Cité, 75006 Paris, France
^P Presenting author

P-2a-21

OXYSTEROLS PROFILE IN ZEBRAFISH EMBRYOS UPON EXPOSURE TO BISPHENOL A (BPA) AT 8 AND 24 HOURS POST-FERTILISATION

Anton Vremere^P1, Carmine Merola², Federico Fanti², Manuel Sergi², Monia Perugini², Dario Compagnone², Michele Amorena², Milena Mikhail¹, Stefano Lorenzetti^1
1 ISS – Istituto Superiore di Sanità, Department of Food Safety, Nutritionn and Veterinary Public Health
² University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment
^P Presenting author

P-2a-22

HIGH CONTENT SCREENING OF BISPHENOLS AND THEIR MIXTURES UNDER CONDITIONS OF LOW-INTENSITY ADIPOGENESIS OF HUMAN MESENCHYMAL STEM CELLS (hMSCs)

Kalle Norgren¹, Astrud Tuck¹, Antero Vieira Silva¹, Paula Burkhardt¹, Mattias Öberg¹, Vesna Munic Kos^P1
1 Karolinska Institutet
^P Presenting author

P-2a-23

Reproductive and developmental adverse effects of complex real-life mixtures in human-relevant cell-based assays

Andreas Frederik Treschow^P1, Yanying Ma¹, Maria João Valente¹, Maria Margalef², Maria König³, Solène Motteau⁴, Gaud Dervilly⁴, Ronan Cariou⁴, Beate I. Escher³, Marja Lamoree², Jean-Philippe  Antignac⁴, Anne Marie Vinggaard^1
1 National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
² Vrije Universiteit, Department Environment & Health, Amsterdam, the Netherlands
³ Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
⁴ Oniris, INRAE, LABERCA, Nantes, France
^P Presenting author

P-2a-24

Teratogenic potential of Cosmetics: Building and Optimize a toolbox to develop an ITS

Matthew Burbank^P1, Florian Gautier¹, Audrey Noel-Voisin¹, Tanja Wildemann¹, Anne Riu¹, Ann Detroyer¹, Typhaine Bringel¹, Laurent Guillet-Revol¹, Leopold Carron¹, Noémie De Croze¹, Gladys Ouédraogo^1
1 L’Oreal Research & Innovation, Aulnay-sous-Bois, France
^P Presenting author

P-2a-25

The role of retinoids in disturbing neural rosette formation

Nadine Dreser^P1, Marion Kapitza¹, Christiaan  Karreman¹, Ilinca Suciu¹, Marcel Leist^1
1 In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp Zbinden Foundation, University of Konstanz
^P Presenting author

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2b. Challenges in cosmetics safety 

P-2b-1

An OECD 439 Adaptive In Vitro Skin Irritation Test Model

Sevde  Altuntas^P1,2,3, Ahmet Katı^1,4,3, Ashwani  Sharma^5
1 Experimental Medicine Research and Application Center, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
² Department of Tissue Engineering, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
³ Omic-A Research and Innovation Ltd Company, Pendik, 34668, Istanbul, Turkey
⁴ Department of Tissue Biotechnology, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
⁵ Insight Biosolutions, 35000, Rennes, France
^P Presenting author

P-2b-2

ToxTool: an innovative database for the cosmetic regulatory affair

Giulia De Negri Atanasio^P1, Federica Robino², Lorenzo Dondero¹, Elisabetta Perata², Francesca  Rispo¹, Giorgia Allaria¹, Francesca  Tardanico¹, Francesca Bruzzone², Matteo Zanotti-Russo², Elena Grasselli^1
1 Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
² ANGEL CONSULTING S.a.s., Italy
^P Presenting author

P-2b-3

Too many Animal Tests on Cosmetic Ingredients for REACH in the EU: actual situation and future prospects

Costanza Rovida^P1, Francois Busquet^2
1 CAAT-Europe, Konstanz University, Germany
² Altertox, Belgium
^P Presenting author

P-2b-4

The study on EDs and the application of the NGRA according to the guidelines SCCS NoG XI Ed: two overlapping challenges.

Matteo Zanotti Russo^P1, Giorgia Allaria², Lorenzo Dondero², Giulia De Negri Atanasio², Francesca Rispo², Francesca Tardanico², Federica Robino¹, Elisabetta Perata¹, Francesca Bruzzone¹, Elena Grasselli^2
1 Angel Consulting S.a.s. 20122 Milano Italy
² Dipartimento Scienze della Terra dell’Ambiente e della Vita-DISTAV, Università degli Studi di Genova—16132 Genova, Italy
^P Presenting author

P-2b-5

Zebrafish: Alternative Model For Cosmetic Testing

Arantza Muriana^P1, Andrea Weiner¹, Celia Rodriguez ^1
1 BBD BioPhenix-BIOBIDE
^P Presenting author

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3a. Models, biomarkers and assays for systemic and immune toxicity  

P-3a-1

Analysis of the predictive capacity of the SENS-IS assay to define the skin sensitization potency on 186 chemicals

Françoise Cottrez¹, Elodie Boite^1
1 ImmunoSearch, Grasse, France
^P Presenting author

P-3a-2

Potential beneficial effects of selenium nanoparticles in the adjuvant anticancer therapy

Elena Ines Adam-Dima^P1, Mihaela Balaș², Anca Dinischiotu², Carmen Nicoleta Purdel¹, Denisa  Margină^1
1 “Carol Davila” University of Medicine and Pharmacy Bucharest, Faculty of Pharmacy
² University of Bucharest, Faculty of Biology
^P Presenting author

P-3a-3

Extending the boundaries of OECD DPRA test N°442C towards complex substances and mixtures: an innovative feat in HPLC-MS/MS and skin sensitization testing

Eric  Andres ^P1, Sergio Gonzalez Duque¹, Axelle Huyard¹, Rola Barcham¹, Christophe Dini^1
1 Oroxcell
^P Presenting author

P-3a-4

Target organs in cosmetics: which in vitro and in silico models to move towards to increase expertise in systemic toxicity?

Matthew Burbank^P1, Emilie Barbeau¹, Romain Grall¹, Ann Detroyer¹, Audrey Noel-Voisin², Gladys Ouedraogo¹, Anne Riu^3
1 L’Oréal Research and Innovation, , Aulnay-sous-Bois, France
² L’Oréal Research and Innovation, , Clichy, France
³ L’Oréal Research and Innovation,, Aulnay-sous-Bois, France
^P Presenting author

P-3a-5

Safety of cosmetic perfumes screened in chemico and in vitro in combination with targeted chemical analysis

Marketa  Dvorakova^P1,2, Kristina Kejlova¹, Hana Bendova¹, Lada Svobodova^1,3, Marian Rucki¹, Vaclav Sevcik^1,4, Barbora Hosikova³, Jan Chrz³, Danuse Ocadlikova¹, Hana Kolarova³, Marek Maly¹, Dagmar Jirova¹, Helena Kandarova^5
1 National Institute of Public Health, Prague, Czech Republic
² Third Faculty of Medicine, Charles University in Prague, Czech Republic
³ Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
⁴ Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Czech Republic
⁵ Slovak Academy of Sciences, Bratislava, Slovak Republic
^P Presenting author

P-3a-6

Use of Assay Ready KertainoSens® Cells to test for Skin Sensitization

Lukas Focke^P1, Valerie de Boor¹, Oliver Wehmeier^1
1 acCELLerate GmbH
^P Presenting author

P-3a-7

A predictive 3D liver spheroid model for the assessment of liver repeated dose toxicity

Romain Grall^P1, Veronique Neiveyans¹, Sylvie Emery¹, Françoise Gautier², Gladys Ouedraogo¹, Anne Riu^1
1 L’Oréal Research and Innovation, Aulnay-sous-Bois, France
² L’Oréal Research and Innovation, Clichy, France.
^P Presenting author

P-3a-8

Developing an innervated skin model for predicting neuroinflammatory and neurosensory effect of cosmetic compounds

Md Zobaer Hasan^P1, Amy Leigh Harding², Hirofumi Nakanishi¹, Tetsuo Furuno¹, Craig  Murdoch², Helen E Colley^2
1 Rohto Pharmaceutical CO.,ltd
² University of Sheffield
^P Presenting author

P-3a-9

EFFECTS OF PER- AND POLYFLUOROALKYL SUBSTANCES IN HUMAN B AND T CELL LINES

Aafke Janssen^P1, Karsten Beekmann¹, Nicole Pinckaers¹, Joke  Hoekstra¹, Sanne  Schild¹, Ron Hoogenboom¹, Ad Peijnenburg¹, Jochem Louisse^1
1 Wageningen Food Safety Research
^P Presenting author

P-3a-10

IN VITRO 3D KIDNEY MODEL CO-CULTURED WITH HUMAN IMMUNE CELLS INVESTIGATING IMMUNE HYPERACTIVITY ASSOCIATED RENAL INJURY

Yu Bin Lee^P1, Mi-lang Kyun¹, Tamina Park¹, Min-Heui Yoo¹, Inhye Kim¹, Hyewon Jung¹, Myeongjin Choi¹, Seo Yule Jeong¹, Jihye Son¹, Dong Ho Woo¹, Chang Hoon Choi¹, Hyun-A Oh¹, Ye-Ji Kim¹, Gong Yeon Kim¹, Yu Yeong Jeong¹, Daeui Park¹, Kyoung-Sik Moon^1
1 Korea Institute of Toxicology
^P Presenting author

P-3a-11

Establishment of a complex commensal 3-D skin model for toxicity testing

Lisa Lemoine^P1, Maya Kissner, Aline Rosin, Tewes Tralau
¹ German Federal Institute for Risk Assessment (BfR)
^P Presenting author

P-3a-12

EXPLORING CAUSAL RELATIONSHIPS BETWEEN PFAS EXPOSURE AND LIPID HOMEOSTASIS BY THE USE OF A HUMAN LIVER SPHEROID MODEL

Birgitte Lindeman^P1, Marit Låg¹, Line Småstuen Haug¹, Azemira Sabaredzovic ¹, Kristine Bjerve Gützkow^1
1 Norwegian Institute of Public Health; Division of Climate and Environmental Health
^P Presenting author

P-3a-13

In vitro study of biosafety of ZnO nanoparticles: coagulation assay and protein corona.

Montserrat Mitjans^P1, Marc Bilbao¹, Laura Marics¹, M. Pilar Vinardell^1
1 Fisiologia, Dep. de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona
^P Presenting author

P-3a-14

Evaluation of the use of in vitro methods to study the general toxic effect of cosmetic products

Ulyana Protasevich^P1, Maryna Anisovich¹, Tatsiana  Hamolka¹, Iryna Ilyukova^1
1 Republican unitary enterprise «Scientific practical centre of hygiene»
^P Presenting author

P-3a-15

LIVER METABOLOMICS IN VITRO– A MINIATURIZED SCREENING APPROACH TO PREDICT THE MODE OF ACTION OF LIVER TOXICANTS IN HEPG2 CELLS

Sabina Ramirez Hincapie^P1, Barbara  Birk¹, Michael  Herold², Philipp  Ternes², Volker  Haake², Varun  Giri¹, Franziska Maria  Zickgraf ¹, Hans-Albrecht  Huener¹, Andreas  Verlohner¹, Hennicke  Kamp¹, Robert  Landsiedel¹, Elke  Richling³, Dorothee  Funk-Weyer¹, Bennard  van Ravenzwaay^1
1 BASF SE
² BASF Metabolome Solution GmbH
³ University of Kaiserslautern
^P Presenting author

P-3a-16

IMPLEMENTING AN IN VITRO METABOLOMICS SCREENING METHOD TO STUDY LIVER TOXICANTS IN HEPG2 CELLS- A CASE STUDY WITH NITROFURANTOIN

Sabina Ramirez Hincapie^P1, Barbara  Birk¹, Franziska Maria Zickgraf¹, Michael  Herold², Philipp Ternes², Volker  Haake², Varun  Giri¹, Hans-Albrecht  Huener¹, Andreas  Verlohner¹, Hennicke  Kamp¹, Robert  Landsiedel¹, Elke  Richling³, Dorothee  Funk-Weyer¹, Bennard  van Ravenzwaay^1
1 BASF SE
² BASF Metabolome Solutions GmbH
³ University of Kaiserslautern
^P Presenting author

P-3a-17

IMPACT OF BENZO[A]PYRENE ON MICRORNAS PROFILES IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS AND THEIR DISCHARGED EXTRACELLULAR VESICLES

Rima Souki^P1, Jeremy  Amosse¹, Maguy  Basbous², Eric  Le Ferrec¹, Dominique Lagadic-Gossmann¹, Christine Demeilliers², Anne Maitre², Lydie Sparfel^1
1 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail),  UMR_S 1085, F-35000 Rennes, France
² Univ. Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC Laboratory (UMR CNRS 5525), EPSP Team, 38000, Grenoble, France
^P Presenting author

P-3a-18

Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis

Jonas van Ertvelde^P1, Anouk Verhoeven¹, Tamara Vanhaecke¹, Ramiro Jover², Jian  Jiang¹, Mathieu  Vinken^1
1 Entity of In Vitro Toxicology and Dermato Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
² Joint Research Unit in Experimental Hepatology, University of Valencia; IIS Hosp. La Fe; CIBERehd; Spain
^P Presenting author

P-3a-19

An adverse outcome pathway network for liver steatosis induced by chemicals

Anouk Verhoeven^P1, Jonas  van Ertvelde ¹, Mathieu Vinken¹, Robim Marcelino Rodrigues¹, Joost Boeckmans¹, Alexandra  Gatzios¹, Sara  Sepehri¹, Marth  Stinckens¹, Ramiro  Jover², Anna  Rapisarda², Birgitte  Lindeman³, Graciela Lopez Soop³, Camilla  Svendsen³, Jian  Jiang¹, Tamara  Vanhaecke^1
1 Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
² Joint Research Unit in Experimental Hepatology, University of Valencia; IIS Hosp. La Fe; CIBERehd; Spain
³ Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway
^P Presenting author

P-3a-20

Advanced biological models for hazard assessment of nanomaterials on human health

Laura Maria Azzurra Camassa^P1, Hamed Sadeghiankaffash¹, Zheng Congying², Kristine Haugen Ammarkrud¹, Sergey Shaposhnikov², Shan Zienolddiny-Narui1^1
1 National Institute of Occupational Health in Norway, 0033 Oslo, Norway
² Norgenotech AS, 0379 Oslo, Norway
^P Presenting author

Go back

3b. Organ-on-a-chip & Microphysiological Systems   

P-3b-1

On the Real-Time Oxygen Consumption of Hepatocytes in a Microphysiological System

Marie Flechner¹, Jan Martin Gebler¹, Christian Gehre¹, Sarah Kammerer², Dennis Kaden³, Jan-Heiner Küpper², Claus Duschl¹, Lars Daehne³, Katja Uhlig^P1
1 Fraunhofer Institute for Cell Therapy and Immunology (IZI-BB), 14476 Potsdam, Germany
² Brandenburg University of Technology, 01968 Senftenberg, Germany
³ Surflay Nanotec GmbH, 12489 Berlin, Germany
^P Presenting author

P-3b-2

PROPOSAL FOR A HUMAN FOETO-PLACENTAL ORGAN-A-CHIP FOR TESTING DEVELOPMENTAL TOXICITY

Emilio Benfenati¹, Michaela Luconi², Udo R. Markert³, Tobias May⁴, Alessandra Roncaglioni¹, Astrid Schmidt⁵, Miguel A. Sogorb^P6, Marco Straccia⁷, Sabrina Tait⁸, Susanne Wolbankh^9
1 Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy
² Dept. Clinical & Experimental Biomedical Sciences, University of Florence, Italy
³ Placenta Lab, Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.
⁴ InSCREENeX GmbH, Braunschweig, Germany
⁵ Placenta Lab, Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany
⁶ Bioengineering Institute, Miguel Hernández de Elche University, 03202-Elche, Spain
⁷ FRESCI by SCIENCE&STRATEGY SL, Barcelona, Spain
⁸ Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy
⁹ Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Donaueschingenstrasse 13, A-1200, Vienna, Austria
^P Presenting author

P-3b-3

ALL-IN-ONE MICROFLUIDIC-BASED ROBOTIC PLATFORM FOR AUTOMATED TOX SCREENINGS IN C. ELEGANS.

Elena  Katsyuba¹, Lazar Stojkovic¹, Fabien Tâche¹, Matteo Cornaglia¹, Laurent Mouchiroud^P1
1 Nagi Bioscience SA, EPFL Innovation Park, Chemin de la Dent d’Oche 1B, CH-1024 Ecublens, Switzerland
^P Presenting author

P-3b-4

Mutagenicity and genotoxicity assessment of a new biopreservative product rich in Enterocin AS-48

Antonio Cascajosa-Lira^P1, Ana Isabel Prieto¹, María Puerto¹, Enrique  Guillamon², Alberto Baños^2,3, Eva  Valdivia³, Ángeles  Jos¹, Ana María Cameán^1
1 Area of Toxicology. Faculty of Pharmacy.Universidad de Sevilla, Profesor García González n°2, 41012 Sevilla, España
² DMC Research Center. Camino de Jayena, 82, 18620 Alhendín, Granada, España
³ Department of Microbiology. Universidad de Granada. Campus de Fuente Nueva.Dr. Severo Ochoa, 18071 Granada, España
^P Presenting author

P-3b-5

A multiorgan-on chip platform for the in vitro investigation of off-target cardiotoxicity of liver-metabolized anticancer drugs

Erika Ferrari^P1, Roberta Visone^1,2, Paola Occhetta^1,2, Marco  Rasponi^1,2
1 Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy
² BiomimX Srl, Milano, Italy
^P Presenting author

P-3b-6

3D human vasculature-on-a-chip: the biological effect of combustible cigarette smoke and vapor from three heated tobacco products on monocyte adhesion to vessels comprising coronary artery endothelial cells

Ayaka Hayashida^P1, Atsuko  Nozawa¹, Kazuhiro  Ohashi¹, Shigeaki Ito^1
1 Scientific Product Assessment Center, Japan Tobacco Inc.
^P Presenting author

P-3b-7

What are the barriers to adoption of new approach methodologies for gastrointestinal toxicity testing? A systematic review of in vitro models of  gastrointestinal toxicity

Alasdair  Irvine^P1, Paul Jochems¹, Roos Masereeuw^1
1 Utrecht University
^P Presenting author

P-3b-8

A systematic review of in vitro models of drug-induced liver injury

Alasdair  Irvine^P1, Vivian  Lehman^2,3, Bart  Spee⁴, Sabine  Fuchs², Ross Masereeuw ⁵, Mathieu  Vinken^6
1 Utrecht Institute for Pharmaceutical Sciences (UIPS), Division of Pharmacology, Utrecht University
² Department of Metabolic Diseases, University Medical Center Utrecht
³ Department of Veterinary Medicine, Utrecht University
⁴ Department of Veterinary Medicine, Utrecht University,
⁵ Utrecht Institute for Pharmaceutical Sciences (UIPS), Division of Pharmacology, Utrecht University
⁶ Department of In Vitro Toxicology, Vrije Universiteit Brussel
^P Presenting author

P-3b-9

USE OF MICROFLUIDIC CHAMBERS IN ENVIRONMENTAL TOXICITY STUDIES USING FISH CELLS AS A MODEL

Gemma Lopez ^P1, Cinta  Porte¹, Xavier  Muñoz², Carlos  Barata^1
1 IDAEA-CSIC
² IMB-CNM-CSIC
^P Presenting author

P-3b-10

SOLUBLE FACTORS ARE INVOLVED IN THE PROPAGATION OF LIVER FIBROSIS IN VITRO

Saskia Schmidt^P1,2, Catherine Messner^1,3, Carine Gaiser¹, Bradley Petkus⁴, Loïc  Burr⁴, Joy Roth⁵, Alexandra Homsy⁵, Felix Kurth⁴, Silvia Generelli⁴, Laura Suter-Dick^1,3
1 School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Muttenz, 4132, Switzerland
² Department of Pharmaceutical Sciences, University of Basel, Basel, 4056, Switzerland
³ SCAHT: Swiss Centre of Applied Human Toxicology, Basel, 4055, Switzerland
⁴ Centre Suisse d’Electronique et de Microtechnique SA (CSEM), Landquart, 7302, and Muttenz, 4132, Switzerland
⁵ Haute Ecole Arc ingénierie (HES-SO), La Chaux-de-Fonds, 2300, Switzerland
^P Presenting author

P-3b-11

A microfluidic-based in vitro reconstruction of synaptic circuits as an alternative model for pharmacologic research

Clelia  Introna^P1,2, Inês  Pereira³, Guochang Lyu⁴, Maria Josè Lopez Martinez^3,5,6, Josep Samitier^3,5,6, Berta  Coll⁷, Jordi Soriano^8,9, Ernest Arenas⁴, Daniel Tornero Prieto^7,2, Josep M. Canals Coll^1,2
1 Laboratory of Stem Cells and Regenerative Medicine, Department of Biomedical Sciences and Creatio – Production and Validation Center of Advanced Therapies, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona; Barcelona, Spain;
² August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
³ Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology BIST, Barcelona, Spain);
⁴ Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⁵ Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain;
⁶ Department of Electronic and Biomedical Engineering, University of Barcelona, Barcelona, Spain.
⁷ Laboratory of Neuronal Stem Cells and Cerebral Damage, Department of Biomedical Sciences and Creatio – Production and Validation Center of Advanced Therapies, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona; Barcelona, Spain.
⁸ Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona, Spain.
⁹ Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona, Spain.
^P Presenting author

P-3b-12

A microfluidic, patient-derived tumor-on chip platform for therapeutic efficacy and safety evaluation of CAR-T cell products

Julia Roosz^1,2
1 NMI Natural and Medical Sciences Institute at the University of Tübingen
² Department of Microphysiological Systems, University of Tübingen, Tübingen, Germany
^P Presenting author

Go back

4a. Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning   

P-4a-1

Adverse Outcome Network For Obesity Initiated By Endocrine Disruptors developed using the AOP-helpFinder tool

Kevin Bernal¹, Florence Jornod¹, Xavier Coumoul¹, Etienne Blanc¹, MinJi Kim², Karine Audouze^P1
1 Université Paris Cité, Inserm U1124, 75006 Paris, France
² Université Sorbonne Paris Nord, Inserm U1124, 75006 Paris, France
^P Presenting author

P-4a-2

Development of a easy-to-use, semantic technology-based knowledgebase containing toxicological information of cosmetic ingredients to assist animal-free risk assessment

Sara Sepehri^P1 , Robim M. Rodrigues¹ , Mona Delagrange¹ , Joery De Kock¹ , Audrey Sanctorum ² , Jan Maushagen ² , Christophe Debruyne ³, Olga De Troyer ² , Tamara Vanhaecke^1
1 Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
² WISE lab, Vrije Universiteit Brussel, Brussels, Belgium
³ Montefiore Institute of Liège University, Quartier Polytech 1, Allée de la Découverte 10, 4000 Liège, Belgium

^P Presenting author

P-4a-3

Three steps to select analogues for skin sensitization prediction using read-across: an exemplary case study with vanillin

Françoise Gauthier¹, Fleur Tourneix¹, Hind Assaf-Vandecasteele¹, Dagmar Bury¹, Nathalie Alépée^P1
1 L’Oreal R&I
^P Presenting author

P-4a-4

Elucidating the Inhibition Mechanism of six FDA-Approved Drugs on P-glycoprotein (P-gp) Transporter by Molecular Docking Simulation

Abira Dey¹, Ruoya Li², Nathalie Larzat², Jean Bernard  Idoipe², Ahmet Kati³, Ashwani SHARMA^P2
1 Indian Science and Technology Foundation, Delhi-110053, India
² Insight Biosolutions, 35000, Rennes, France
³ Experimental Medicine Research and Application Center, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey, Department of Biotechnology, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey,
^P Presenting author

P-4a-5

ORBITOX – A COMPUTATIONAL TRANSLATIONAL DISCOVERY PLATFORM FOR DATA MINING AND READ-ACROSS

Alexander  Sedykh¹, Austin  Ross¹, Vijay  Gombar¹, Nicole  Kleinstreuer², Alex  Merick³, Ruchir  Shah¹, Warren  Casey^3
1 Sciome LLC
² NICEATM, NIEHS
³ NTP, NIEHS
^P Presenting author

P-4a-6

Use of text-mining and chemoinformatics as additional decision-making tools for the chemical selection process of the EU-NETVAL thyroid validation study

David  Asturiol^P1, Alessandro  Antonelli², Anna  Beronius³, Patience Browne⁴, Thomas  Cole¹, Raffaella Corvi¹, Barbara  Demeneix⁵, Alexius  Freyberger⁶, Mary Gilbert Gilbert⁷, Elise  Grignard¹, Klára Hilscherová⁸, Aude Kienzler¹, Dries Knapen⁹, Josef  Kӧhrle¹⁰, Ingrid Langezaal¹, Sharon  Munn¹, Amalia  Munoz Pineiro¹, Gea  Oliveri Conti¹¹, Alicia  Paini¹, Alex  Patak¹, Mauro Petrillo¹, Daniel  Pickford¹², Francesca  Pistollato¹, Anna  Price¹, Antonio  Puertas Gallardo¹, Maddalena  Querci¹, Barbara Raffael¹, Kostja  Renko¹⁰, Tammy  Stoker⁷, Jukka  Sund¹, Guy  Van den Eede¹³, Michael  Wade¹⁴, Maurice Whelan¹, Sandra Coecke^1
1 European Commission, Joint Research Centre, Italy
² University of Pisa, Italy
³ Karolinska Institutet, Sweden 
⁴ OECD, France
⁵ National Museum of  Natural History
⁶ Bayer AG
⁷ US Environmental Protection Agency, USA
⁸ Masaryk University, Czechia
⁹ University of Antwerp, Belgium
¹⁰ Charité-Universitӓtsmedizin, Germany
¹¹ University of Catania, Italy
¹² Syngenta, UK
¹³ European Commission, Joint Research Centre
¹⁴ Health Canada, Canada
^P Presenting author

P-4a-7

IMPLEMENTATION OF IN SILICO-BASED READ-ACROSS ASSESSMENT FOR GENOTOXICITY FOR PESTICIDE RESIDUES UNDER EU LEGISLATION AND KEY CHALLENGES

Minako  Allen^P1, Maria  Pellizzaro ¹, Rebecca Silcock^1
1 Exponent International Ltd
^P Presenting author

P-4a-8

Development and validation of machine learning based QSAR models to predict the TPO inhibitors

Bharath BR^P1, Vaibhav Barot¹, Rahul Date¹, Abhay Deshpande^1
1 Jai Research Foundation
^P Presenting author

P-4a-9

High throughput in vitro genotoxicity methods for hazard identification and characterization of “data poor” compounds

Steve Bryce^P1, Jeff Bemis¹, Stephen  Dertinger¹, Stephanie Smith-Roe², Kristine Witt^2
1 Litron Laboratories, Rochester NY
² Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC
^P Presenting author

P-4a-10

Combining gene expressions and imaged-based morphological features for chemical-phenotype profiles

Natacha Cerisier^P1, Bryan Dafniet¹, Olivier Taboureau^1
1 Université Paris Cité, INSERM U1133, CNRS UMR8251, 75006, Paris, France.
^P Presenting author

P-4a-11

Development and Translation of Quantitative Neuronal Adverse Outcome Pathway (qNAOP) model for Neurotoxicity Risk Assessment

Deepika Deepika^P1, Raju Prasad Sharma¹, Marta Schuhmacher¹, Vikas Kumar^1
1 Environmental Engineering Laboratory, Departament d’Enginyeria Quimica, Universitat Rovira i Virgili, Av. Països Catalans 26, 43007 Tarragona, Catalonia, Spain
^P Presenting author

P-4a-12

CONTRIBUTION MAPPING: USING STRUCTURE–TOXICITY RELATIONSHIPS (STR) AND MECHANISTIC INTERPRETABILITY OF IN SILICO MODELS TO ASSESS DEVELOPMENTAL TOXICITY AND ENDOCRINE-DISRUPTING POTENTIAL OF TWELVE UV FILTERS

Andrezza Di Pietro Micali Canavez^P1, Carlos  Eduardo Matos dos Santos ², Desiree Cigaran Schuck¹, Marcio  Lorencini^1
1 Grupo Boticário
² Altox Ltd
^P Presenting author

P-4a-13

Physiological map to study kidney toxicity in the ONTOX project

Alessio Gamba^P1, Luiz Carlos Maia Ladeira¹, Raphaëlle Lesage², Daniël Roodzant³, Devon Barnes⁴, Manoe Janssen⁴, Marc Teunis³, Rosalinde Masereeuw⁴, Liesbet Geris^1,2,5, Bernard Staumont^1
1 Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium.
² Skeletal Biology and Engineering Research Center, KU Leuven, Belgium.
³ Innovative testing in Life Sciences & Chemistry, Utrecht University of Applied Sciences, The Netherlands.
⁴ Div. Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
⁵ Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Belgium.
^P Presenting author

P-4a-14

QUANTITATIVE ADVERSE OUTCOME PATHWAY MODELING FOR CHRONIC TOXICITY

Shigeaki Ito^P1, Sayak Mukherjee², Kazuo Erami¹, Shugo Muratani¹, Akina Mori¹, Sakuya Ichikawa¹, Kei Yoshino¹, Dawn Fallacara^2
1 Scientific Product Assessment Center, Japan Tobacco Inc., 6-2, Aoba-ku, Yokohama, Japan
² Battelle, 505 King Ave., Columbus, OH 43201
^P Presenting author

P-4a-15

Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis

Jian jiang^P1, Jonas van Ertvelde¹, Gökhan Ertaylan², Ralf Peeters^3,4, Danyel Jennen⁵, Theo de Kok^3,5, Mathieu Vinken^1
1 Entity of In Vitro Toxicology and Dermato‑Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
² Vlaamse Instelling voor Technologisch Onderzoek (VITO) NV, Health, Boeretang 200, 2400 Mol, Belgium
³ Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands
⁴ Department of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands
⁵ Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands
^P Presenting author

P-4a-16

Virtual Human Platform for Safety Assessment (VHP4Safety): Assessing the safety of chemicals and pharmaceuticals based on human data

Anne Kienhuis^P1, Cyrille Krul², Juliette Legler^3
1 National Institute for Public Health and the Environment (RIVM)
² University of Applied Sciences Utrecht (HU)
³ Utrecht University
^P Presenting author

P-4a-17

A COMPARATIVE COMPUTATIONAL PREDICTION OF THE BINDING OF ANDROGEN- AND ESTROGEN-LIKE FLAVONOIDS TO THEIR COGNATE (NON)NUCLEAR RECEPTORS

Stefano Lorenzetti^P1, Giulia D’Arrigo², Eleonora Gianquinto², Giulia Rossetti³, Gabriele Cruciani⁴, Francesca Spyrakis^2
1 ISS – Istituto Superiore di Sanità, Department of Food Safety, Nutritionn and Veterinary Public Health
² University of Turin, Department of Drug Science and Technology
³ Aachen University, Department of Neurology
⁴ University of Perugia, Department of Chemistry, Biology and Biotechnology
^P Presenting author

P-4a-18

Designing physiological maps as a tool to study liver toxicology

Luiz Carlos Maia Ladeira^P1, Alessio Gamba¹, Raphaëlle Lesage², Anouk Verhoeven³, Jonas  van Ertvelde³, Jian Jiang³, Daniël Roodzant⁴, Marc Teunis⁴, Ramiro Jover⁵, Tamara Vanhaecke³, Mathieu Vinken³, Harm  Heusinkveld⁶, Liesbet Geris^1,2,7, Bernard Staumont^1
1 Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium
² Skeletal Biology and Engineering Research Center, KU Leuven, Belgium
³ Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium
⁴ Innovative Testing in Life Sciences & Chemistry, University of Applied Sciences Utrecht, The Netherlands
⁵ Dept. Biochemistry, University of Valencia, IIS Hosp. La Fe, CIBERehd, Spain
⁶ Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
⁷ Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Belgium
^P Presenting author

P-4a-19

Toxicity prediction of mycotoxins by in silico modeling

Martina Palomino-Schätzlein^P1, Josefa Tolosa², Eva Serrano-Candelas¹, Jose Luis Vallés-Pardo¹, Salvador  Moncho¹, Rafael Gozalbes^1
1 ProtoQSAR SL, CEEI, Parque Tecnológico de Valencia (Av. Benjamin Franklin 12, 46980, Paterna, Valencia, Spain)
² Laboratory of Toxicology. Faculty of Pharmacy. University of Valencia (Av. Vicent Andrés Estellés s/n. 46100. Burjasot, Valencia, Spain)
^P Presenting author

P-4a-20

Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and toxicokinetic data gaps within the ONTOX project

Alessandra Roncaglioni^P1, Domenico Gadaleta¹, Erika Colombo¹, Eva Serrano-Candelas², Pablo Aparicio², Rafael Gozalbes², Emilio Benfenati^1
1 Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
² ProtoQSAR SL, Valencia, Spain
^P Presenting author

P-4a-21

Development new web-tool for phototoxicity prediction on the base of machine learning approach

Marta Šoltésová Prnová^P1,2, Matej Halinkovič², Tibor Sloboda², Kateřina Mušková², Patrik Pavlačka², Jakub Knánik², Helena Kanďárová^1
1 Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia
² Faculty of Informatics and Information Technologies Slovak University of Technologies in Bratislava, Slovakia
^P Presenting author

P-4a-22

QSAR MODEL FOR PREDICTING MYCOTOXIN MUTAGENICITY

Josefa Tolosa^P1, Martina Palomino-Schätzlein², Eva Serrano-Candelas², José Luis Vallés-Pardo², Salvador Moncho², Rafael Gozalbes^2
1 University of Valencia
² ProtoQSAR
^P Presenting author

P-4a-23

Computational modelling of neural tube closure defects

Job Berkhout^P1,2, Aldert Piersma^1,2, Juliette Legler², Alessio Gamba³, Luiz Carlos Maia Ladeira³, Bernard Staumont³, Raphaëlle Lesage⁴, Liesbet Geris^3,4,5, Harm Heusinkveld^1
1 RIVM, the Netherlands
² IRAS, Utrecht University, The Netherlands
³ GIGA In Silico Medicine, University of Liège, Belgium
⁴ Skeletal Biology and Engineering Research Center, KU Leuven, Belgium
⁵ Biomechanics Section, KU Leuven, Belgium
^P Presenting author

P-4a-24

ASSESSING A BATTERY OF IN SILICO MODELS AS PREDICTION TOOL FOR COMPOUNDS EXERTING REPRODUCTIVE HEALTH EFFECTS

Serhii Kolesnyk^1,2, Mykola Prodanchuk², Yana Kolianchuk², Nataliia Bubalo³, Alex Odermatt¹, Martin Smiesko^1
1 Department of Pharmaceutical Sciences, University of Basel, Switzerland
² L.I.Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Kyiv, Ukraine
³ Jaksch Lifescience Consulting GmbH
^P Presenting author

P-4a-25

Facilitating modern toxicology with Natural Language Processing

Marie Corradi^P1, Alyanne de Haan¹, Thomas Luechtefeld^2,3, Marc Teunis^1
1 Hogeschool Utrecht
² ToxTrack
³ CAAT
^P Presenting author

P-4a-26

Using molecular docking simulations to elucidate molecular initiating event (MIE) interactions of neonicotinoid pesticides and human nicotinic acetylcholine receptors (nAChRs)

Karin Grillberger^P1, Gerhard F. Ecker^1
1 University of Vienna
^P Presenting author

Go back

4b. Local toxicity testing (safety and efficacy)

P-4b-1

Concentration, typology of surfactants, in vitro and clinical ocular tolerance studies: a multi-parameterized approach for foaming cosmetics intended to claim “do not sting the eyes”

Rakotomalala Sandrine¹, Berrada-Gomez Marie-Pierre^P1, Baco David², Ferret Pierre-Jacques^1
1 Safety Assessment Department, Pierre Fabre Dermo-Cosmétique, Toulouse, France
² Global Innovation Center Department, Pierre Fabre Dermo-Cosmétique, Toulouse, France
^P Presenting author

P-4b-2

Effect of a modulator on the skin sensitization potency of cosmetic fragrance formulations

Carine LINOSSIER¹, Marine CUSCUSA¹, Marisa MELONI², Andy FORRERYD³, Mylène LANVIN^1
1 COTY
² VITROSCREEN
³ SENZAGEN
^P Presenting author

P-4b-3

Comparison between HET-CAM protocols and a product use clinical study for eye irritation evaluation of personal care products according to their surfactant composition

Martín Nicolás Rivero¹, Mariela Lenze¹, Mercedes Izaguirre^1,2, Martina Benedetti^1,2, Silvia Pérez Damonte³, Silvia Wikinski^1,2, María Laura Gutiérrez^P1,2
1 Institute of Pharmacology – University of Buenos Aires
² CONICET
³ CLAIM CRO
^P Presenting author

P-4b-4

DECISION TREE FOR OCULAR SAFETY ASSESSMENT OF AGROCHEMICAL FORMULATIONS

Martín Nicolás Rivero¹, Mariela Lenze^1,2, Agustina Reschini¹, Juan Ignacio Pina³, Romina Martinez⁴, Silvia Wikinski^1,2, María Laura Gutiérrez^P1,2
1 Institute of Pharmacology – University of Buenos Aires
² CONICET
³ ATANOR SCA
⁴ Dr Julio Mendez Hospital
^P Presenting author

P-4b-5

THE RECONSTRUCTED HUMAN EPIDERMIS (RHE) EFFICIENCY IN THE CLASSIFICATION OF BIOLOGICAL PRODUCT BY THE IN VITRO IRRITATION AND CORROSION TESTS (OECD 439 AND 431).

Bruna Assunção Bechtold¹, Julio César Cianci², Maria ´Paula Mancini Coelho³, Leandro Fernando Felix⁴, Thatiane Nunes Santana⁵, Vanja Dakic⁶, Rodrigo De Vecchi⁶, Luis Paulo Fava⁷, Priscilla Muniz Ribeiro da Silva⁸, Juliana Falcato Vecina^P8
1 Specialist, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil
² Laboratory Assistant, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil
³ Laboratory Analyst; Merieux NutriSciences (Bioagri Laboratórios Ltda)
⁴ Trainee, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil
⁵ Laboratory technique, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil
⁶ Researcher, Episkin Academy, Rio de Janeiro-RJ, Brazil
⁷ Coordinator; Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁸ Researcher; Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
^P Presenting author

P-4b-6

PROFICIENCY DEMONSTRATION OF MERIEUX NUTRISCIENCE (BIOAGRI LABORATÓRIOS LTDA) ON IN VITRO EYE IRRITATION AND SERIOUS EYE DAMAGE IMPLEMENTATION

Maria Paula Mancini Coelho¹, Bruna Assunção Bechtold², Julio César Cianci³, Larissa Gabriele Costa³, Leandro Fernando Felix⁴, Thatiane Nunes Santana⁵, Vanja Dakic⁶, Rodrigo De Vecchi⁶, Luis Paulo Fava⁷, Priscilla Muniz Ribeiro da Silva⁸, Juliana Falcato Vecina^P8
1 Laboratory Analist; Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
² Specialist, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
³ Laboratory Assistant, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁴ Trainee, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁵ Laboratory Technique, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁶ Researcher, Episkin Academy, Rio de Janeiro-RJ, Brazil
⁷ Coordinator, Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁸ Researcher; Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
^P Presenting author

P-4b-7

SkinEthic™ HCE Time-to-Toxicity : World’s first adopted new approach methodology on its own for eye hazard identification adopted by OECD

Nathalie Alépée¹, Frédéric Amaral^P1, Virginie Leblanc¹, Laurent Nardelli¹, Valérie Tagliati², Séverine Teluob², Anaelle Viricel², Valérie Michaut^1
1 L’Oreal R&I
² Episkin SA
^P Presenting author

P-4b-8

COMPOUND A-111 – A NOVEL SMALL MOLECULE CANDIDATE FOR THE TOPICAL TREATMENT OF HYPERPIGMENTATION

Agnieszka Gunia-Krzyżak¹, Justyna Popiół², Magda Borczuch-Kostańska¹, Katarzyna Wójcik-Pszczoła², Paulina Koczurkiewicz-Adamczyk², Patryk Kasza³, Przemysław Szafrański³, Dorota  Żelaszczyk¹, Elżbieta Pękala^2
1 Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland
² Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland
³ Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland
^P Presenting author

P-4b-9

Corneal-derived biomolecular solution: application as an in chemico method for ocular toxicity assessment

Jordana Andrade Santos¹, Wanessa Amorim Dias¹, Artur Christian  Garcia da Silva^P1, Marize  Campos Valadares^1
1 Laboratory of Research and Education in In Vitro Toxicology, Federal University of Goiás, Goiânia, Goiás, Brazil
^P Presenting author

P-4b-10

A new approach for Eye Hazard Assessment of surfactants based on in vitro Test Methods

Els Adriaens^P1, Nathalie Alépée², Takayuki Abo³, Dan Bagley⁴, Jason Magby⁴, Arianna Giusti⁵, Karsten Mewes^6
1 Adriaens Consulting, Belgium
² L’Oréal R&I, France
³ Kao Corporation, Japan
⁴ Colgate Palmolive, United States
⁵ Cosmetics Europe, Belgium
⁶ Henkel AG & Co. KGaA, Germany
^P Presenting author

P-4b-11

DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL USING LIVE-CELL IMAGING: APPLICATION IN DERMATOLOGY AND COMSETIC FIELDS

Manon Barthe^P1, Jean-Paul Thénot², Hanan Osman-Ponchet^2
1 PKDERM Laboratories
² PKDERM SAS
^P Presenting author

P-4b-12

A NEW HUMAN IN VITRO SKIN MODEL OF EPIDERMAL BARRIER DAMAGE

Manon Barthe^P1,2, Véronique M. Braud², Jean-Paul Thénot³, Hanan Osman-Ponchet^3
1 PKDERM Laboratories
² Université Côte d’Azur, CNRS UMR7275, Institut de Pharmacologie Moléculaire et Cellulaire – France
³ PKDERM SAS
^P Presenting author

P-4b-13

Study of the efficacy and safety on in vitro human skin models of a Curcumin emulsion for skin pathologies treatment

Mónica Betanzos^P1, Adrian  García¹, Senda Basasoro², Paloma Gómez¹, Garazi Berra², Gartze Mentxaka¹, Amaia  García¹, Nagore Gabilondo², Felipe Goñi de Cerio^1
1 GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, Spain
² Materials & Technologies’ Research Group (GMT), Department of Chemical and Environmental Engineering, Faculty of Engineering of Gipuzkoa, University of the Basque Country, Donostia-San Sebastian, Spain
^P Presenting author

P-4b-14

Cutaneous tolerance of personal care products dedicated to babies and adults with sensitive skin:  in vitro/in vivo correlation

Marie-Pierre Gomez-Berrada^P1, Hélène Recoules¹, Sophie Catoire², Laetitia Beaudequin², Adeline Josseaume², Pierre-Jacques Ferret^1
1 Safety Products Department, Pierre Fabre Dermo Cosmetique, Toulouse, France
² Cell Alternativ, Trosly Breuil, France
^P Presenting author

P-4b-15

Retrospective review on in vitro phototoxicity data generated in 3D skin models to support development of new OECD test guideline

Helena Kandarova^P1, Hans  Raabe², Allison  Hilberer², Neepa Choksi³, Dave  Allen^3
1 Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovak republic
² Institute for In Vitro Sciences, Inc., 30 W. Watkins Mill Road, Suite 100, Gaithersburg, Maryland 20878, United States
³ Integrated Laboratory Systems, Inc., 601 Keystone Park Drive, Suite 800, Morrisville, NC, 27560, United States
^P Presenting author

P-4b-16

ESTABLISHMENT OF A COMMENSAL 3D SKIN MODEL FOR STUDYING MICROBIAL MODULATION OF PESTICIDE TOXICITY

Maya Kissner^P1, Aline Rosin¹, Tewes Tralau², Lisa Lemoine^1
1 German Federal Institute for Risk Assessment, Department Pesticides Safety, Junior Research Group Skin Microbiome
² German Federal Institute for Risk Assessment, Department Pesticides Safety
^P Presenting author

P-4b-17

Determination and Sub-categorization of Ocular Irritants Using the EpiOcular Tissue Model – Prediction Models for Liquids and Solids

Silvia Letasiova^P1, Lenka Hudecova¹, Jan Markus¹, Yulia  Kaluzhny², Mitch Klausner^2
1 MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
² MatTek Corporation, Ashlad, MA, USA
^P Presenting author

P-4b-18

SAFETY AND EFFICACY TESTING OF COSMETIC PRODUCTS: OVERVIEW OF ESTABLISHED METHODS AND NEW MODELS.

Hanan Osman-Ponchet^P1, Manon Barthe², Jean-Paul Thénot^1
1 PKDERM SAS
² PKDERM Laboratories
^P Presenting author

P-4b-19

In vitro evaluation of safety profile of a cosmetic ingredient – 4-methoxychalcone

Justyna Popiół^P1, Karolina Słoczyńska¹, Paulina Koczurkiewicz-Adamczyk¹, Dorota Żelaszczyk², Katarzyna Orzeł², Katarzyna Wójcik-Pszczoła¹, Przemysław  Szafrański³, Patryk Kasza³, Elżbieta Pękala¹, Agnieszka Gunia-Krzyżak^2
1 Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University – Medical College
² Department of Bioorganic Chemistry, Faculty of Pharmacy, Jagiellonian University – Medical College
³ Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University – Medical College
^P Presenting author

P-4b-20

Pre-Clinical in vitro assessment of tobacco-free nicotine pouch products

Sarah Jean Pour^P1, Roman  Wieczorek¹, Edgar Trelles Sticken¹, Ole  Dethloff¹, Liam Simms², Matthew Stevenson^2
1 Reemtsma Cigarettenfabriken GmbH
² Imperial Brands PLC
^P Presenting author

P-4b-21

Skin sensitization of “challenging” compounds: in vitro strategy applied to bio-based ingredients

Mickaël PUGINIER^P1, Alicia Roso^1
1 Seppic, 50 boulevard National, CS 90020, 92257 La Garenne Colombes Cedex, France
^P Presenting author

P-4b-22

Measurement and culture method of organoid for toxicity assessment of nanomaterials

Ahruem Baek^P1, Tae Geol Lee¹, Min Beom Heo^1
1 Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS)
^P Presenting author

P-4b-23

New based on cell assay to evaluate eye stinging potential of chemicals and cosmetic formulations

Marize Valadares^P1, Lara  Brito ¹, Carolina Motter  Catarino², Artur C Garcia Silva ¹, Desiree Cigaran  Schuck², Andrezza Di Pietro Micali  Canavez^2
1 Federal Univeristy of Goiás
² Grupo Boticario
^P Presenting author

P-4b-24

Cytotoxicity Profile and Prooxidant Effects of the New Ruthenium Complex HE-10 in Human Skin Fibroblast Cells

Hande Özbaşak^P1, Hani  Elbeheiry², Martin  Schulz², Mojmír  Mach¹, Lucia  Račková^1
1 Centre of Experimental Medicine Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia
² Friedrich Schiller University Jena, Institute of Physical Chemistry, Jena, Germany
^P Presenting author

P-4b-25

Application of fluorescence-based methods for in chemico and in vitro detection of photoreactive chemicals

Hande Özbaşak^P1, Hani  Elbeheiry², Martin  Schulz², Mojmír  Mach¹, Lucia  Račková¹

Káren do Carmo Gonçalves¹, Artur Christian Garcia da Silva^P1, Jordana Andrade Santos¹, Marize Campos Valadares^1
1 Laboratory of Research and Education in In vitro Toxicology (Tox In) – Faculty of Pharmacy – Federal University of Goiás (UFG)
^P Presenting author

Go back

5a. Toxicokinetics and in vitro – in vivo extrapolation

P-5a-1

In vitro biotransformation of propyl-propane-thiosulfonate (PTSO): Identification and characterization of metabolites

Antonio Cascajosa-Lira^P1, Concepción  Medrano-Padial¹, Silvia Pichardo¹, Alberto Baños², Enrique Guillamón², Ángeles  Jos¹, Ana M. Cameán^1
1 Area of Toxicology. Faculty of Pharmacy. University of de Seville, Profesor García González n°2, 41012 Seville, Spain.
² DMC Research Center. Camino de Jayena, 82, 18620 Alhendín, Granada, Spain.
^P Presenting author

P-5a-2

Preliminary results to the determination of dermal toxicological reference  values for a neurotoxic organophosphorus agent

Marie-Laure Cointot^P1, Lysiane Champion², Alan Hubert², Jennifer Millerioux², Anne Bossée^2
1 French Ministry for Armed Forces
² French Ministry for Armed Forces
^P Presenting author

P-5a-3

Preliminary results to the determination of dermal toxicological reference  values for a neurotoxic organophosphorus agent

Marie-Laure COINTOT^P1, Lysiane CHAMPION¹, Alan HUBERT¹, Jennifer MILLERIOUX¹, Anne BOSSE^1
1 French Ministry of Armed Forces
^P Presenting author

P-5a-4

PBK Modelling Of In Vivo Distribution Kinetics In The ONTOX Project

René Geci^P1,2, Alicia Paini², Stephan Schaller², Huan Yang², Lars Küpfer^1
1 University Hospital RWTH Aachen, 52074 Aachen, Germany
² esqLABS GmbH, Hambierich 34, 26683 Saterland, Germany
^P Presenting author

P-5a-5

Developing toxicokinetic models for chemical risk assessment of Homosalate using MOIE – a Cosmetics Europe Case Study

Anne Moustié^P1, Nazanin Golbamaki¹, Matthew Burbank¹, Laurène Roussel-Berlier¹, Guillaume Lereaux¹, Françoise Gautier², Audrey  Noel-Voisin², Nicky Hewitt³, Gladys Ouédraogo¹, Sébastien Grégoire^1
1 L’Oréal R&I Advanced research, Aulnay-sous-Bois, France
² L’Oréal R&I-Saint-Ouen France
³ Cosmetic Europe, Brussels, Belgium
^P Presenting author

Go back

5b. In vitro systems to assess respiratory toxicity  

P-5b-1

INHALATION TOXICITY ASSESSMENT OF AN AEROSOLIZED SUNSCREEN PRODUCT WITH AN IN VITRO PULMONARY MODEL

Béatrice BUI¹, Marie-Pierre GOMEZ-BERRADA^P1, Pierre-Jacques FERRET^1
1 Safety Products Department, Pierre Fabre Dermo Cosmetique, Toulouse, FRANCE
^P Presenting author

P-5b-2

Novel fully primary human airway epithelium-alveolar macrophages in vitro co-cultures models to study host pathogen interactions

Bernadett  Boda¹, Samuel Constant ^P1
1 Epithelix
^P Presenting author

P-5b-3

Utilisation of human 3D bronchial tissues for e-cigarette assessment

Matthew  Stevenson¹, Lukasz  Czekala^P1, Roman Wieczorek¹, Edgar Trelles Sticken¹, Sarah  Jean Pour ¹, Fiona  Chapman¹, Liam Simms^1
1 Imperial Brands PLC
^P Presenting author

P-5b-4

Electronic Nicotine Delivery Systems exhibit lower toxicity compared to cigarettes: The Replica Study experience

Massimo Caruso^P1,2, Alfio Distefano¹, Rosalia Emma¹, Sonja Rust³, Konstantinos Poulas^4,5, Fahad Zadjali⁶, Silvia Boffo⁷, Antonio Giordano⁷, Vladislav Volarevic⁸, Konstantinos Mesiakaris^4,5, Georgios Karanasios⁵, Mohammed  Al Tobi⁶, Najwa Albalushi⁶, Angelo Canciello⁷, Aleksandar Arsenijevic⁸, Aleksandar Ilic⁸, Tancredi Caruso¹, Giuseppe Carota¹, Mariarita Spampinato¹, Roberta Pulvirenti¹, Pietro Zuccarello⁹, Margherita Ferrante⁹, Riccardo Polosa^10,2, Giovanni Li Volti^1,2
1 Department of Biomedical and Biotechnological Sciences, University of Catania, (Italy)
² Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, (Italy)
³ ECLAT Srl, spin-off of the University of Catania, (Italy)
⁴ Institute for Research and Innovation, IRIS, Patras Science Park, Patras (Greece)
⁵ Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, Patras (Greece)
⁶ College of Medicine and Health Sciences, Department of Clinical Biochemistry, Sultan Qaboos University (Oman)
⁷ Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University (USA)
⁸ Center for Molecular Medicine and Stem Cell Research, Department of Microbiology and Immunology, Faculty of Medical Sciences University of Kragujevac (Serbia)
⁹ Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania (Italy)
¹⁰ Department of Clinical and Experimental Medicine, University of Catania (Italy)
^P Presenting author

P-5b-5

IN VITRO AIR-LIQUID INTERFACE EXPOSURE OF LUNG CELLS TO THERAPEUTIC AEROSOLS FOR PRECLINCAL DRUG DEVELOPMENT

Evelien Frijns^P1, An Jacobs¹, Jo Van Laer¹, Karen Hollanders¹, Sylvie Remy¹, Dirk Jochmans², Sandra Verstraelen^1
1 VITO NV, Unit HEALTH, Boeretang 200, 2400 Mol, Belgium
² REGA Institute KU Leuven, Herestraat 49, 3000 Leuven, Belgium
^P Presenting author

P-5b-6

New concepts in inhalation toxicology: The in vitro approach

Tanja Hansen^P1, Detlef Ritter¹, Jan Knebel¹, Nico Sonnenschein¹, Norman Nowak¹, Sylvia Escher¹, Katharina  Blümlein¹, Katharina Schwarz^1
1 Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany
^P Presenting author

P-5b-7

UNDERSTANDING THE TOXICITY OF A BTEX MIXTURE: AIR/LIQUID INTERFACE EXPOSURE OF ORGANOTYPIC LUNG CULTURES

Nour Jaber^P1, Claude  Emond², Fabrice  Bray³, Paul  Genevray⁴, Christian  Rolando³, Fabrice  Cazier⁴, Sylvain  Billet^1
1 UR4492, Unité de Chimie Environnementale et Interactions sur le Vivant, SFR Condorcet FR CNRS 3417, Université du Littoral Côte d’Opale, Dunkerque, France.
² PKSH Inc, Département de Santé Environnementale et Santé au Travail de l’Ecole de santé publique, Université de Montréal, Canada.
³ Univ. Lille, CNRS, UAR 3290, MSAP, Miniaturisation pour la Synthèse l’Analyse et la Protéomique, F-59 000, Lille, France.
⁴ CCM, Centre Commun de mesure, Université du Littoral Côte d’Opale, Dunkerque, France.
^P Presenting author

P-5b-8

Fine dust toxicity evaluation on uterus using endometrial stem cells

Soo-Rim Kim^P1,2, Se-Ra Park^1,2, Seong-Kwan Kim^1,2, In-Sun Hong^1,2
1 Laboratory of stem cell research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.
² Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 406-840, Republic of Korea.
^P Presenting author

P-5b-9

Flavors in e-cigarettes – a tasty hazard?

Selina Rinaldi^P1, Elke  Pieper¹, Nadja Mallock¹, Peter Laux¹, Andreas Luch^1
1 German Federal Institute for Risk Assessment – Department for Chemical and Product Safety
^P Presenting author

P-5b-10

Dosimetry in inhalation: an in vitro inhalation model to study the relevance of dose parameters related to particle mass and particle number

Detlef Ritter^P1, Katharina Schwarz¹, Wolfgang Koch^1
1 Fraunhofer ITEM
^P Presenting author

P-5b-11

Development of alternative in vitro and ex vivo models for testing of inhalable antibiotics

Katharina Schwarz^P1, Sabine  Wronski¹, Detlef Ritter¹, Jan Knebel¹, Katharina Bluemlein¹, Sven Cleeves¹, Nico Sonnenschein¹, Laura Mueller¹, Monika Niehof¹, Katherina Sewald¹, Tanja Hansen¹, Norman Nowak¹, Armin Braun^1
1 Fraunhofer Institute for Toxicology and Experimental Medicine
^P Presenting author

P-5b-12

Ex vivo porcine precision cut lung slices (PCLS) for pulmonary toxicity assessment

Katharina Schwarz^P1, Sabine  Wronski¹, Detlef Ritter¹, Jan Knebel¹, Katharina Bluemlein¹, Sven Cleeves¹, Nico Sonnenschein¹, Laura Mueller¹, Monika Niehof¹, Katherina

Marcella Miranda Siqueira  Furtuoso¹, Bruna Cristiane Oliveira  Pedralli¹, Marize Valadares^P2
1 Federal Univeristy of Goiás
² Federal University of Goiás
^P Presenting author

Go back

6a. In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines  

P-6a-1

Liver spheroid co-cultures with fresh or cryopreserved hepatocytes and endothelial cells as tool to investigate metabolism and hepatotoxicity

Jana Moer¹, David Kwapiszewski¹, Anett Ullrich^P1, Simon Beuck², Madlen Matz-Soja³, Andrea Zimmermann^4
1 Primacyt Cell Culture Technology GmbH
² A&M Labor Service GmbH
³ Lehrstuhl für Allgemeine Biochemie, Universität Leipzig
⁴ Hepatobiliäre Chirurgie und viszerale Transplantation, Sächsischer Inkubator für klinische Translation
^P Presenting author

P-6a-2

A novel polymer generates cell repellent surfaces and allows 3D cell culture

Anett Ullrich¹, Veronique Schwartz², Dieter Runge^P1
1 Primacyt Cell Culture Technology GmbH, Schwerin, Germany
² Chemovator GmbH, Mannheim, Germany
^P Presenting author

P-6a-3

Use of Assay Ready THP-1 derived macrophages to test for pyrogen contamination

Adrian Dittberner¹, Lukas Focke^P1, Mirta Jacobs¹, Karen Hinsch^1
1 acCELLerate GmbH
^P Presenting author

P-6a-4

Validation of the ToxProfiler reporter assay and its application in mechanistic toxicity testing

Bas ter Braak¹, Liesanne Wolters¹, Giel Hendriks¹, Torben Osterlund^P1
1 Toxys B.V.
^P Presenting author

P-6a-5

Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker

Inger Brandsma¹, Remco Derr¹, Gaonan  Zhang¹, Nynke Moelijker¹, Giel Hendriks¹, Torben Osterlund^1
1 Toxys B.V.
^P Presenting author

P-6a-6

Exploring the use of spheroid cultures of human liver cells for the mechanistic testing of carcinogenic compounds

Bruna dos Santos Rodrigues¹, Prashant Kadam^P1, Kaat  Leroy¹, Sarah  Vanbellingen², Joeri L.  Aerts², Mathieu Vinken^1
1 Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
² Entity of Neuro-Aging and Viro-Immunotherapy, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
^P Presenting author

P-6a-7

In vitro study of the potential of new liposomal delivery systems for future medical applications in inhalation therapies

Juliana Carrillo Romero^1,2, Amaia Garcia Bilbao^P1, Laura Fernández Méndez², Adrian Garcia¹, Alberto Katsumiti¹, Pedro  Ramos Cabrer^2,3, Susana  Carregal Romero^2,3,4, Felipe Goñi de Cerio^1
1 GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, 48170 Spain
² Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastián, 20014 Spain
³ Ikerbasque, Basque Foundation for Science, Bilbao, 48013 Spain
⁴ CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 28029 Spain
^P Presenting author

P-6a-8

In vitro microenvironment modifies the neurotoxic response of SH-SY5Y cells

Véronique De Conto¹, Vaihere Cheung¹, Gregory Maubon¹, Zied Souguir¹, Nathalie Maubon¹, Elodie Vandenhaute¹, Vincent Berezowski^2
1 HCS Pharma
² Lille Neuroscience and Cognition, U1172
^P Presenting author

P-6a-9

THE POTENTIAL OF 3D CELL-BASED PLATFORMS FOR THE SCREENING OF NOVEL DRUG CANDIDATES TARGETING THE HEPATIC PLASMODIUM INFECTION

Francisca Arez^P1,2, Diana Fontinha³, Sofia P. Rebelo^4,2, Christoph Fischli^5,6, Claude Oeuvray⁷, Manuel  Carrondo^4,2, Matthias Rottmann^5,6, Thomas Spangenberg⁷, Catarina Brito^4,2, Beatrice Greco⁷, Miguel  Prudêncio³, Paula M Alves^4,2
1 iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal
² Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
³ Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal
⁴ iBET,  Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal
⁵ Swiss TPH, Basel 4051, Switzerland
⁶ University of Basel, Basel 4003, Switzerland
⁷ Merck Global Health Institute, Ares Trading S.A., Route de La Verrerie 6, CH-1267, Coinsins, Switzerland, a subsidiary of Merck KGaA, Darmstadt Germany
^P Presenting author

P-6a-10

The potential of 3D reconstructed Human intestinal models for biowaiver studies and finished products testing

Rola BARCHAM^P1, Eric ANDRES¹, Axel HUYARD¹, Christophe DINI^1
1 Oroxcell, 102 avenue Gaston Roussel, 93230 Romainville, France
^P Presenting author

P-6a-11

Mechanistic Investigation of Drug-Induced Liver Toxicity using Human 3D InSight Liver Model

Anna Borgström^P1, Katarzyna Sanchez¹, Friederike Wenz¹, Natalia  Zapiórkowska-Blumer¹, Armin  Wolf ¹, Bruno Filippi^1
1 InSphero AG, Wagistrasse 27a, 8952 Schlieren, Switzerland
^P Presenting author

P-6a-12

Use of 3D human liver microtissues to assess hepatotoxicity of biologics

Reiner Class^P1, Andrea Kiessling¹, Breda Twomey¹, Milena Mennecozzi¹, Monika Kijanska², Agata Gorecka^2
1 UCB Biopharma
² InSphero AG
^P Presenting author

P-6a-13

MTS application as alternative in vitro method to assess the toxicity of veterinary autogenous vaccines produced at Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”: preliminary data.

Claudia Colabella^P1, Lucia Anzalone¹, Martina Pellegrini¹, Giulio Saveri¹, Monica Cagiola¹, Antonella Di Paolo^1
1 Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”, via G. Salvemini 1, 06126 Perugia, Italy
^P Presenting author

P-6a-14

In vitro microenvironment modifies the neurotoxic response of SH-SY5Y cells

Véronique DE CONTO^P1, Vaihere Cheung¹, Gregory  MAUBON¹, Zied Souguir¹, Nathalie Maubon¹, Elodie Vandenhaute¹, Vincent Berezowski^2
1 HCS Pharma
² Lille Neuroscience and Cognition, U1172
^P Presenting author

P-6a-15

Interplay between in vitro off-target pharmacological promiscuity, cytotoxicity, and in vivo tolerability in rodents to improve the safety profile of anti-malarial drug discovery

Helga Gerets^P1, Annie Delaunois¹, Alicia Sibony¹, Reiner Class¹, Teresa De Haro Garcia¹, Benoit Laleu², Martin  Lowe³, Renaud Fleurance¹, Marie-Luce Rosseels¹, Jean-Pierre Valentin^1
1 UCB BioPharma SRL
² MMV
³ exscientia
^P Presenting author

P-6a-16

USEFULNESS OF THE ZEBRAFISH EMBRYO MODEL TO EVALUATE NEW THERAPIES AGAINST MULTIDRUG-RESISTANT BACTERIA

Laura Guzman^P1, Cristina  Marqués¹, Elena  Sánchez-López^2,3,4, Amanda  Cano^2,3,4, Antoni  Camins^4,5,6, Yolanda  Cajal², Miren  Ettcheto^4,5,6, Francesc  Rabanal⁷, Marta  Barenys^1,8
1 GRET i Unitat de Toxicologia, Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i  Ciències de l’Alimentació, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain
² Unitat de Fisicoquímica, Departament de Farmàcia, Tecnologia farmacèutica i fisicoquímica, Facultat de Farmàcia i  Ciències de l’Alimentació, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31,08028 Barcelona, Spain
³ Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona (UB), Av. Diagonal, 64, 08028 Barcelona, Spain.
⁴ Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.
⁵ Unitat de Farmacologia, Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31,08028 Barcelona, Spain
⁶ Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d’Hebron, 171, 08035 Barcelona, Spain
⁷ Unitat de Química Orgànica, Departament de química inorgànica i orgànica, Facultat de Química, Universitat de Barcelona (UB), C/Martí i Franquès, 1-11, 08028 Barcelona, Spain
⁸ Institut de Recerca en Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), Av. Prat de la Riba, 171, 08921 Barcelona, Spain
^P Presenting author

P-6a-17

Induction and evaluation of an oxidative stress response in the EpiDermFT in vitro human skin model

Jan Markus^P1, Silvia Letasiova¹, Kaitlyn Marengo², Jon Oldach², Alex Armento², Anna Langerveld³, Elisabeth Lehigh^3
1 MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
² MatTek Corporation, Ashland, MA, USA
³ Genemarkers LLC, Kalamazoo, MI
^P Presenting author

P-6a-18

hiPSCs and hiPSCs-derived renal proximal tubular cells showed different response to nephrotoxic compounds

Isaac Musong Mboni Johnston^P1, Nicole Schupp^1
1 Heinrich Heine University hospital, Institute of Toxicology
^P Presenting author

P-6a-19

Low Endotoxin Recovery (LER) effect in pharmaceutical products analyzed with the Monocyte Activation Test (MAT).

Marco Mingolla^P1,2, Chiara Celli², Fabrizio Lecce^2
1 Università degli Studi di Torino, Molecular Medicine, Torino, Italy
² Merck KGaA, Istituto di Ricerche Biomediche “A. Marxer” RBM S.p.A., Ivrea, Italy
^P Presenting author

P-6a-20

An epidermal model containing melanocytes for skin pigmentation and lightening studies

Marek Puskar^P1, Bridget Breyfogle², Seyoum Ayehunie², Silvia Letasiova¹, Jon Oldach², Alex Armento², Mitchell Klausner^2
1 MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
² MatTek Corporation, Ashland, MA, USA
^P Presenting author

P-6a-21

PITFALLS OF THE MTT ASSAY AND CYTOTOXICITY EVALUATION OF TRADITIONAL ANTIMALARIALS

Lucia Rackova^P1
1 Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Dubravska cesta 9, 841 04 Bratislava, Slovakia
^P Presenting author

P-6a-22

Long-term upregulation in drug metabolization and hepatic gene expression in primary human hepatocytes (PHH) after exogenous exposure to human intestinal microbiome secretome peptides

Natalia Sánchez-Romero^P1,2, Pilar  Sainz de la Maza Arnal^1,2, Maria Jesús Lozano Limones^1,2, Mario  Fernández Sanz², Álvaro  Blanes Rodríguez², Sandra  Meliton Barbancho², Pedro Baptista^2,3,4,5
1 Cytes Biotechnologies
² Health Research Institute of Aragón (IIS Aragón)
³ Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid
⁴ ARAID Foundation
⁵ CIBERehd
^P Presenting author

P-6a-23

Novel in vitro approaches in safety evaluation of cemtirestat

Marta Šoltésová Prnová^P1,2, Peter Pôbiš¹, Marek Lepáček¹, Lucia Račková¹, Jana Viskupičová¹, Tea Lanišnik Rižner³, Sreeparna Banerjee⁴, Helena Kanďárová⁵, Milan Štefek^5
1 Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia
² Faculty of informatics and information technologies Slovak University of Technologies in Bratislava, Slovakia
³ Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
⁴ Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
⁵ nstitute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia
^P Presenting author

P-6a-24

Drug-induced QTc prolongation and Torsades de Pointes: evolving ICH S7B in light of emerging in silico, in vitro and in vivo data and implication for drug development

Jean-Pierre VALENTIN^P1, Derek LEISHMAN², Hugo VARGAS^3
1 UCB Biopharma, Braine l’Alleud, Belgique
² Eli-Lilly, Indianapolis, USA.
³ Amgen, California, USA
^P Presenting author

P-6a-25

Novel Human-Relevant Preclinical Safety Testing Strategy for Recombinant Human Monoclonal Antibodies Directed Against Foreign Targets

April Naab¹, Jeffrey Brown^P1, Esther Wenzel², Stefan Dübel², Paul Stickings³, Michael Hust^2
1 PETA Science Consortium International e.V.
² Technische Universität Braunschweig
³ National Institute for Biological Standards and Control
^P Presenting author

P-6a-26

Hepatic 3D cell models as a cell-based biosensor-like system for the in vitro (geno)toxicity testings

Martina  Štampar^P1,2, Barbara  Breznik¹, Sonja Žabkar¹, Metka  Filipič¹, Bojana Žegura^1
1 National Institute of Biology, Department for Genetic Toxicology and Cancer Biology
² Jozef Stefan International Postgraduate School, Slovenia
^P Presenting author

P-6a-27

Development of a primary culture system to investigate compound toxicity in steatotic hepatocytes

Anett Ullrich^P1, Tim Brecklinghaus², Jan G. Hengstler², Dieter Runge^1
1 PRIMACYT Cell Culture Technology GmbH
² Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund
^P Presenting author

P-6a-28

LONG-TERM RECORDING OF CARDIAC ACTION POTENTIALS FOR CHRONIC CARDIOTOXICITY ASSESSMENT

Giuseppina Iachetta¹, Giovanni Melle², Nicolò  Colistra², Francesco De Angelis¹, Michele Dipalo^P1
1 Istituto Italiano di Tecnologia
² Foresee Biosystems srl
^P Presenting author

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6b. Knowledge sharing and education  

P-6b-2

Ukrainian National 3Rs Center. An effective tool to advance the 3Rs principles by focusing on their scientific impacts and benefits

Nataliia Bubalo^P1, Serhii Kolesnyk¹, Petro Zhminko¹, Marina Zinovieva¹, Yana  Kolianchuk¹, Inna Rashkivska^1
1 L.I.Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety Ministry of Health, Ukraine
^P Presenting author

P-6b-3

Reproducibility in Cell Culture: Replacing Fetal Bovine Serum

Tilo Weber^P1, Kristina Wagner ¹, Jessica Rosolowski¹, Joachim Wiest^2
1 Animal Welfare Academy of the German Animal Welfare Federation, Neubiberg, Germany
² cellasys GmbH, Kronburg, Germany
^P Presenting author

P-6b-4

FUN with NAMs

francois busquet^P1
1 altertox
^P Presenting author

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7a. Developmental Neurotoxicity (DNT)  

P-7a-1

Developmental toxicity assessment of nanoparticles: The importance of indirect placenta-mediated toxicity mechanisms

Battuja Dugershaw-Kurzer^1,2, Patrycja  Nowak-Sliwinska^3,4, René Hornung⁵, Arjan Griffioen⁶, Judy R. van Beijnum⁶, Stefan Masjosthusmann⁷, Ellen Fritsche⁷, Tina Buerki-Thurnherr^P1
1 Laboratory for Particles Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, Switzerland
² Laboratory of Toxicology, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
³ Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland
⁴ Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
⁵ Department of Gynaecology and Obstetrics, Kantonsspital St.Gallen, St. Gallen, Switzerland
⁶ Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands
⁷  IUF – Leibniz Research Institute for Environmental Medicine, Duesseldorf, German
^P Presenting author

P-7a-2

DEVELOPMENTAL NEUROTOXICITY OF ACRYLAMIDE AND ITS METABOLITE GLYCIDAMIDE IN A HUMAN MIXED CULTURE OF NEURONS AND ASTROCYTES UNDERGOING DIFFEFRENTIATION

Oddvar Myhre^P1, Malene Lislien¹, Jørn A Holme², Hubert Dirven¹, Ragnhild E Paulsen³, Inger Margit Alm¹, Ellen Skarpen⁴, Vigdis Sørensen⁴, Peter Macko⁵, Francesca Pistollato⁵, Nur Duale¹, Anna J Lauvås^1
1 Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.
² Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
³ Department of Pharmacy, University of Oslo, Norway
⁴ Core Facility for Advanced Light Microscopy, Institute for Cancer Research, Oslo University Hospital, Norway
⁵ European Commission, Joint Research Centre (JRC), Ispra, Italy
^P Presenting author

P-7a-3

In vitro study of fumonisin B1 and ochratoxin A on undifferentiated SH-SY5Y cells and contribution of beetroot in alleviating toxic effects

Raquel Penalva-Olcina^P1, Mónica  Fernández-Franzón¹, Ana Juan-García^1
1 Universitat de València
^P Presenting author

P-7a-4

APPLIYING NAMS TO SAFETY EVALUATION OF HERBAL PRODUCTS CONSUMED BY CATALAN PREGNANT AND LACTATING WOMEN: INTERVIEW-BASED CONSUMPTION SURVEY AND DEVELOPMENTAL NEURO/TOXICITY EVALUATION IN ZEBRAFISH EMBRYOS

Noelia G Romero^P1, Elisabet  Teixidó^1,2, Nicole  Feliu¹, Salvador  Cañigueral³, Jesús  Gómez-Catalán^1,2, Marta  Barenys^1,2
1 GRET and Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27 31, Barcelona, Spain.
² Institute of Nutrition Research and Food Safety (INSA UB), University of Barcelona, Barcelona, Spain.
³ Unitat de Farmacologia, Farmacognòsia, i Terapèutica, Facultat de Farmàcia, i Ciències de l’Alimentació, Universitat de Barcelona, Av. Joan XXIII  27-31, 08028 Barcelona, Spain.
^P Presenting author

P-7a-5

Application of a human in vitro testing battery for endocrine disruptor (ED)-induced developmental neurotoxicity (DNT) to refine EDC hazard assessment

Katharina Koch^P1, Kevin Schlüppmann¹, Saskia Hüsken¹, Louisa Stark¹, Arif Dönmez¹, Nils Förster^2,3, Ellen Fritsche^1,4
1 Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany
² Bioinformatics Group, Department of Biology and Biotechnology, Ruhr-University Bochum, Bochum, Germany
³ Bioinformatics, Center for Protein Diagnostics (ProDi), Ruhr-University Bochum, Bochum, Germany
⁴ Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
^P Presenting author

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7b. Implementation of NAMs into regulatory frameworks – establishing scientific confidence, development of standards and good practices  

P-7b-1

INCREASING PREDICTIVITY OF COMPOUND MULTI-ORGAN TOXICITY THROUGH HIGH-THROUGHPUT ZEBRAFISH ASSAYS

Carles Cornet^P1, Valentina Schiavone¹, Sergio Jarque¹, Maria Rubio-Brotons¹, Víctor Ordoñez ¹,  UPC data science  cours participants ², Jessica García-Fernández¹, Ferran Arqué¹, Rafael  Miñana-Prieto¹, Javier Terriente¹, Sylvia Dyballa¹, Vincenzo Di Donato^1
1 ZeClinics – IGTP research centre, Barcelona (SPAIN)
² Universitat Politècnica de Catalunya · Barcelona Tech – UPC 
^P Presenting author

P-7b-2

LARGE SCALE MANUFACTURING OF NAMS

Karina Cuanalo-Contreras^P1, Dennis Benkmann^1
1 SABEU GmbH & Co. KG
^P Presenting author

P-7b-3

Development of a new methodology to quantify the activation of the Nrf2 (key event 2) by allergens

Bruna  Pedralli¹, Maria de Fátima Barbosa  Costa², Marize Valadares^P2
1 Laboratory of Education and Research in Toxicology In Vitro – Tox In – Pharmacy Faculty, Federal University of Goiás
² Laboratory of Education and Research in Toxicology In Vitro – Tox In –  Pharmacy Faculty, Federal University of Goiás
^P Presenting author

P-7b-4

Reduction of animal use in reproductive and developmental toxicity studies – new methodology approach

Yana Kolianchuk¹, Arne Jaksch¹, Jenny Keicher¹, Nataliia Bubalo<sup>1

1</sup>JAKSCH LIFESCIENCE CONSULTING GmbH

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8a. In vitro methods for safety assessment of medical devices

P-8a-1

Optimization of skin sensitization testing strategy in vitro for medical device extracts

Lada Svobodova^1,2, Kristina Kejlova^P1, Alena Vlkova¹, Marian Rucki¹, Dagmar Jirova¹, Hana Kolarova^2
1 National Institute of Public Health Prague
² Faculty of Medicine and Dentistry, Department of Medical Biophysics, Palacký University
^P Presenting author

P-8a-2

In vitro method for quantitative potency assessment of skin sensitizers during development of novel materials for intended use in medical devices

Ulrika Mattson¹, Karla Lienau², David Waeckerlin², Robin Gradin¹, Rose-Marie Jenvert ^P1
1 SenzaGen AB
² Sonova AG
^P Presenting author

P-8a-3

Development, pre-validation and validation of the EpiDerm in vitro skin irritation protocol for the medical devices extracts

Silvia Letasiova^P1, Jan  Markus¹, Bridget  Breyfogle², Michael A.  Bachelor², Helena  Kandarova^3
1 MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
² MatTek Corporation, Ashland, MA, USA
³ Centre of Experimental Medicine SAS, Slovak Academy of Sciences, Bratislava, Slovakia
^P Presenting author

P-8a-4

Bio-compatibility assessment of medical devices using reconstructed in vitro 3D human cornea-like tissue model

Peter  Pôbiš^P1, Lucia Milec¹, Zuzana Straková¹, Helena Kandarova^1
1 Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia
^P Presenting author

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8b. In vitro COVID-19 research / Lung and cardiovascular models

P-8b-1

COMPARISON OF EXPRESSION PROFILE OF SARS-COV-2 KEY RECEPTORS IN SKIN AND LUNG IN VITRO MODELS

Manon Barthe^P1,2, Véronique M. Braud², Jean-Paul Thénot³, Hanan Osman-Ponchet^3
1 PKDERM Laboratories
² Université Côte d’Azur, CNRS UMR7275, Institut de Pharmacologie Moléculaire et Cellulaire – France
³ PKDERM SAS
^P Presenting author

P-8b-2

INTESTINAL ADVERSE OUTCOMES IN COVID-19: CURRENT EVIDENCE AND UNCERTAINTIES USING THE ADVERSE OUTCOME PATHWAY FRAMEWORK.

Laure-Alix Clerbaux^P1, Julija Fillipovska², Amalia Muñoz³, Mauro Petrillo⁴, Helena Soares⁵, Sally Mayasich⁶, Maria-Joao Amorim⁷, Lucia Grenga^8
1 European Commission, Joint Research Centre (JRC), Ispra, Italy
² Independent scientist, Ohrid, North Macedonia
³ European Commission, Joint Research Centre (JRC), Geel, Belgium
⁴ Past affiliation: European Commission, Joint Research Centre (JRC), Ispra, Italy. Current affiliation: Seidor Italy srl, Milano, Italy
⁵ Human Immunobiology and Pathogenesis Group, CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal
⁶ University of Wisconsin-Madison Aquatic Sciences Center at US EPA, Duluth, MN, USA
⁷ Instituto Gulbenkian de Ciência, Lisbon, Portugal
⁸ Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé, Paris, France
^P Presenting author

P-8b-3

COVID-19 through the lens of the Adverse Outcome Pathways: What can we learn from the view on the relationship between ACE2 dysfunction and its interaction with SARS-COV2

Julija Filipovska^P1,2
1 Independent Scientist, Ohrid, North Macedonia
² The work was inspired and performed as part of the CIAO project (https://www.ciao-covid.net/)
^P Presenting author

P-8b-4

Potential role of quercetin in modulating SARS-CoV-2-induced cytokine storm

Elodie OLIVIER^P1, Mélody DUTOT^1,2, Patrice RAT^1
1 Laboratoire de Chimie Analytique et Toxicologie Expérimentale Toxicologie Cellulaire (UMR CNRS 8038), Faculté de Pharmacie de Paris – Université de Paris
² Yslab, 2 rue Félix Le Dantec, 29000 Quimper, France
^P Presenting author

P-8b-5

ESTROGENIC ACTIVITY RELATED TO THE PRESENCE OF SARS-COV-2 IN WASTEWATER

Francesca Rispo^P1, Lorenzo  Dondero¹, Giulia  De Negri Atanasio¹, Giorgia  Allaria¹, Francesca Tardanico ¹, Stefano Rosatto², Marta Bellisomi², Giulia Palumbi², Irene Tomesani², Alberto Izzotti³, Elena Nicosia², Elena Grasselli^1
1 Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
² ARPAL Liguria, Italy
³ Department of Experimental Medicine, University of Genoa, Genova, Italy
^P Presenting author

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9. Models and methods  

P-MODELS-1

APPLICATION OF BENCHMARK DOSE APPROACH FOR ASSESSMENT OF EFFECTS ON RED BLOOD CELLS REVEALED DURING NON-CLINICAL TOXICITY STUDY OF DRUG CANDIDATE

Mykola Prodanchuk¹, Zhminko Peter¹, Maryna Zinovieva^P1, Serhii Kolesnyk^1
1 L.I.Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine, Kyiv
^P Presenting author

P-MODELS-2

IN VITRO TRANSCRIPTIONAL BIOMARKERS INVOLVED IN LIVER STEATOSIS AND MIXTURE EFFECTS OF HEPATOTOXIC PESTICIDES THROUGH AN ADVERSE OUTCOME PATHWAY-BASED APPROACH

Efrosini Katsanou¹, Anastasia  Spyropoulou^P1, Petros Batakis¹, Dajana Lichtenstein², Claudia Luckert², Albert Braeuning², Alfonso Lampen², Kyriaki Machera^1
1 Laboratory of Pesticides’ Toxicology, Department of Pesticides Control and Phytopharmacy, Benaki Phytopathological Institute, Athens, Greece
² German Federal Institute for Risk Assessment, Dept. Food Safety, Berlin, Germany
^P Presenting author

P-MODELS-3

Thermodynamic study on efficient removal of Cr(III), Cu(II) and Cd(II) heavy metal ions by SnO2/MWCNT nanocomposite.

Shima Mohamad Khani¹, Mahdieh Bazargani², Nikoo Hosseini^1
1 Islamic Azad University, Science and Research Branch ,Tehran ,Iran.
² Sharif University of Technology,Tehran,Iran.
^P Presenting author

P-MODELS-4

PANORAMIX: Providing risk assessments of complex real-life mixtures for the protection of Europe’s citizens and the environment

Anne Marie Vinggaard¹, Marja  Lamoree², Beate  I. Escher³, Jean-Philippe Antignac⁴, Martin  Scholze⁵, Tina Kold Jensen⁶, Matthias Herzler⁷, Marc Audebert⁸, Timo Hamers², Andreas  Kortenkamp⁵, François  Busquet⁹, Matteo Piumatti^P9, Gaud  Dervilly⁴, Maria  João Valente¹, Ronan  Cariou⁴, Solène  Moteau⁴, Michael  Oelgeschläger⁷, Kostja  Renko⁷, Sebastian  Schmeisser⁷, Dieter  Maier¹⁰, Lone  Ladegaard Laursen^11
1 National Food Institute, Technical University of Denmark, Kemitorvet Building 202, 2800 Kgs. Lyngby, Denmark
² Vrije Universiteit, Department Environment & Health, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands
³ Department of Cell Toxicology, Helmholtz Centre for Environmental Research – UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, Schnarrenbergstr. 94-96, DE-72076 Tübingen, Germany.
⁴ Oniris, INRAE, LABERCA, Nantes, France
⁵ Brunel University London, Institute of Environment, Health and Societies, Kingston Lane, Uxbridge, Middlesex UB8 3PH, United Kingdom
⁶ Dep of Environmental Medicine, University of Southern Denmark, Denmark
⁷ German Federal Institute for Risk Assessment (BfR), Department Chemicals and Product Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany
⁸ PrediTox, Toulouse, France
⁹ Altertox Academy, Brussels, Belgium
¹⁰ Biomax Informatics, Planegg, Germany
¹¹ Faculty of Health Science, University of Southern Denmark, Denmark
^P Presenting author

P-MODELS-5

IN VITRO MUTAGENICITY AND GENOTOXICITY OF PURE ANATOXIN-A

Cristina Plata-Calzado¹, Concepcion Medrano-Padial¹, Leticia Diez-Quijada¹, Ana I Prieto¹, Ana M Camean¹, Angeles Jos^P1
1 Area of Toxicology. Faculty of Pharmacy. Universidad de Sevilla. Spain
^P Presenting author

P-MODELS-6

Mutagenenicity and genotoxicity evaluation of reduced graphene oxide by the mouse lymphoma assay and standard and enzyme- modified comet assays

Oscar Cebadero-Dominguez¹, Concepcion Medrano-Padial¹, Maria Puerto¹, Ana M Camean¹, Angeles Jos^P1
1 Area of Toxicology. Faculty of Pharmacy. Universidad de Sevilla. Spain
^P Presenting author

P-MODELS-7

GLIMPSES INTO IN VITRO TESTING OF MYCOTOXIN MIXTURES: INTERACTION BETWEEN TOXINS AND THEIR METABOLIC ACTIVATION

Mohammad Abdulkader Akbarsha^P1, Loganathan Gayathri², Dharumadurai Dhanasekaran², Albert P Li^3
1 Mahatma Gandhi-Doerenkamp Centre (MGDC), Bharathidasan University, Tiruchirappalli 620024, India. Present address: National College (Autonomous), Tiruchirappalli 620001, India
² Department of Microbiology, Bharathidasan University, Tiruchirappalli 620024, India
³ In Vitro ADMET Laboratories LLC, 9221 Rumsey Road, Columbia, MD 21045, USA
^P Presenting author

P-MODELS-8

Regulation of cholesterol transport and metabolism by tumor necrosis factor alpha in a human in vitro blood-brain barrier model

Rodrigo Azevedo Loiola^P1, Shiraz Dib¹, Lucie Dehouck¹, Emmanuel Sevin¹, Jens Pahnke², Fabien Gosselet^1
1 Université d’Artois – France
² University of Oslo, Norway
^P Presenting author

P-MODELS-9

Development of an adverse outcome pathway for kidney tubular necrosis

Devon Barnes^P1, Alasdair Irvine¹, Alessio Gamba², Luiz Carlos Maia Ladeira², Bernard Staumont², Huan Yang³, Inger-Lise Steffensen⁴, Liesbet Geris^2,5,6, Manoe Janssen¹, Rosalinde Masereeuw^1
1 Utrecht Institute for Pharmaceutical Sciences, Utrecht University
² Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège
³ esqLABS
⁴ Department of Food Safety, Norwegian Institute of Public Health
⁵ Skeletal Biology and Engineering Research Center
⁶ Biomechanics Section, Department of Mechanical Engineering
^P Presenting author

P-MODELS-10

Neurotoxic effect of potential countermeasures in case of nerve agent poisoning

Tena Čadež^P1, Zrinka Kovarik^1
1 Institute for Medical Research and Occupational Health, Zagreb, Croatia
^P Presenting author

P-MODELS-11

New Salmonella strains resistant to sulfonylurea and  triazole-pyrimidine herbicides and their use in the Ames test

Olga Egorova^P1, Nataliya Suzina^2,3, Nataliya Ilyushina^1
1 The Federal Budgetary Establishment of Science «Federal Scientific Center of Hygiene named after F.F. Erisman» of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
² G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms
³ Federal Research Center «Pushchino Center for Biological Research of the Russian Academy of Sciences»
^P Presenting author

P-MODELS-12

BPS DISPLAYS SIMILAR PHENOTYPIC AND METABOLIC RESPONSES TO BPA IN HEPG2 AND INS-1E CELLS

Lara Ferreira Azevedo^P1,2, Mauro Miguel Masiero², Sarah Cherkaoui², Maria Fernanda Hornos Carneiro ^1,3, Fernando  Barbosa Júnior¹, Nicola Zamboni^2
1 Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto, Brazil
² Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
³ Facultad de Química y de Farmacia, Campus San Joaquín Pontificia Universidad Católica de Chile, Santiago, Chile
^P Presenting author

P-MODELS-13

Comparison of a heated tobacco stick product and a combustible cigarette: chemical analysis and in vitro toxicological evaluation

Tsuneo Hashizume^P1, Shinkichi Ishikawa¹, Shigeaki Ito¹, Toshiro Fukushima^1
1 Japan Tobacco Inc.
^P Presenting author

P-MODELS-14

A High Content Analysis approach for a better detection of bacterial factors involved in the virulence of Bacillus cereus and Clostridium perfringens Strains

Kevin Hogeveen^P1, Rachelle Lanceleur¹, Abdelrahim Abakabir-Mahamat¹, Olivier Firmesse¹, Valérie  Fessard^1
1 French Agency for Food, Environmental and Occupational Health and Safety
^P Presenting author

P-MODELS-15

Investigation of toxicokinetic and toxikodynamic mixture effects within plant protection products using new approach methodologies: a case study of two products containing tebuconazole + prothioconazole and cypermethrin + piperonylbutoxide

Mawien Karaca^P1,2, Christian Tobias Willenbockel¹, Tewes Tralau¹, Denise Bloch¹, Philip Marx-Stoelting^1,2
1 German Federal Institute for Risk Assessment
² Technical University of Berlin
^P Presenting author

P-MODELS-16

CHRONIC LOW-DOSE EXPOSURE TO DIBUTYL PHTHALATE AFFECTS NO PRODUCTION, CELL MIGRATION, AND ANGIOGENESIS IN HUMAN ENDOTHELIAL CELL LINE EA.HY926

Dunja Kokai^P1, Bojana Stanic¹, Biljana Tesic¹, Dragana Samardzija Nenadov¹, Kristina Pogrmic-Majkic¹, Svetlana Fa Nedeljkovic¹, Nebojsa Andric^1
1 University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Serbia
^P Presenting author

P-MODELS-17

Mixture effects of extracts from environment, food and blood on neurite outgrowth compared to cytotoxicity in SH-SY5Y cells

Jungeun Lee^P1, Marc Audebert², Jean-Philippe Antignac³, Laure Khoury⁴, Maria König¹, Marja Lamoree⁵, Maria Margalef Jorne⁵, Solene Motteau³, Chrstina Rørbye⁶, Rita Schlichting¹, Anne-marie Vinggaard⁷, Maria João Valente⁷, Beate Escher^1
1 Department of Cell Toxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany
² INRAE UMR1331 TOXALIM, France
³ Oniris, INRAE, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments, 44300 Nantes, France
⁴ Preditox, Toulouse, France
⁵ Department Environment & Health, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands
⁶ Hvidovre Hospital, Denmark
⁷ National Food Institute, Technical University of Denmark, Lyngby, Denmark
^P Presenting author

P-MODELS-18

Connexin-based channel activity is not specifically altered by hepatocarcinogenic chemicals

Kaat Leroy^P1, Axelle Cooreman¹, Raf Van Campenhout¹, Bruno  Cogliati², Mathieu Vinken^1
1 Entity of In vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel
² Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo
^P Presenting author

P-MODELS-19

STUDY OF CITRININ TOXIC EFFECTS ON A 3D NEUROBLASTOMA MODEL: CYTOTOXICITY, OXIDATIVE STRESS AND CELL DEATH

Francisco J.  Martí-Quijal^P1, Noemi Torriero^2,3, Francisco J.  Barba¹, María José  Ruiz¹, Maria Rosaria  Esposito^2,3, Elisa Cimetta^2,3
1 Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Valencia, Spain
² Department of Industrial Engineering (DII), University of Padua, Via Marzolo 9, 35131, Padova, Italy
³ Fondazione Istituto di Ricerca Pediatrica Città Della Speranza (IRP) – Lab BIAMET, Corso Stati Uniti 4, 35127, Padova, Italy
^P Presenting author

P-MODELS-20

THE ROLE OF ENVIRONMENTAL CONTAMINANTS DETECTABLE IN WASTE OF ELECTRICAL AND ELECTRONIC EQUIPMENT (WEEE) PLANTS IN A549 AND HEPG2 CELL LINES – THE VAISAL PROJECT

Milena Mikhail^P1, Alessandra Di Veroli², Anton  Vremere¹, Stefano Di Bona², Francesca Buiarelli³, Giulia Simonetti³, Patrizia Di Filippo⁴, Donatella Pomata⁴, Carmela Riccardi⁴, Franco Lucarelli⁵, Giulia Pazzi⁵, Roberta Galarini⁶, Carolina Barola⁶, Simone Moretti⁶, Fabiola Paoletti⁶, Laura Goracci², Gabriele Cruciani², Stefano Lorenzetti^7
1 ISS – Istituto Superiore di Sanità, Department of Food Safety, Nutritionn and Veterinary Public Health
² University of Perugia, Department of Chemistry, Biology and Biotechnology
³ University Sapienza of Rome, Department of Chemistry
⁴ INAIL-DIT
⁵ University of Florence, Department of Physics
⁶ Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche ”Togo Rosati”
⁷ ISS – Department Food Safety, Nutrition and Veterinary Public Health
^P Presenting author

P-MODELS-21

PK-driven drug test for the evaluation of the efficacy of anti-cancer treatment regimens

Andrey Poloznikov^P1, Martin Schumacher¹, Sergey Nikulin^1
1 MimiQ GmbH
^P Presenting author

P-MODELS-22

INTEGRATED ENVIRONMENTAL AND HUMAN IN VITRO TOXICITY APPROACH FOR DINOFLAGELLATES

Cristina Scarone^P1, Susanna Alloisio², Francesco Misurale¹, Valentina  Giussani³, Laura Pezzolesi⁴, Rossella Pistocchi⁴, Antonio Novellino², Aldo Pagano¹, Anna Maria Bassi^1
1 Department of Experimental Medicine- University of Genoa, Italy
² ETT Spa, Italy
³ ARPAL Liguria, Italy
⁴ University of Bologna, Italy
^P Presenting author

P-MODELS-23

INTEGRATEIDENTIFICATION OF A NOVEL MODE OF ACTION OF VANILLIN DERIVATIVE COMPOUND VERATRALDEHYDE

Taku Watanabe^P1, Satoru Munakata¹, Tomohiro Takahashi¹, Shiori Kimuro¹, Tsuneo Hashizume^1
1 Japan Tobacco Inc.
^P Presenting author

P-MODELS-24

Using an in vitro inflamed intestinal model to study the effect of deoxynivalenol on primary bile acid malabsorption in human

Jingxuan Wang^P1, Wouter Bakker¹, Laura de Haan¹, Hans Bouwmeester^1
1 Division of Toxicology, Wageningen University and Research
^P Presenting author

P-MODELS-25

Use of RNA seq-based gene expression signatures of pesticide active substances in human kidney cells to support definition of cumulative assessment groups (CAGs) for risk assessment

Aafke Janssen¹, Karsten Beekmann¹, Deborah Rijkers¹, Valerie van der Vorst¹, Hans Mol¹, Ad Peijnenburg¹, Jochem Louisse^P1
1 Wageningen Food Safety Research
^P Presenting author

P-MODELS-26

Receptor-mediated activities of 4- and 5-ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in relation to their developmental toxicity potency

Jing Fang^P1, Danlei Wang¹, Ivonne Rietjens¹, Peter Boogaard¹, Lenny Kamelia^2
1 Division of Toxicology, Wageningen University and Research
² Shell Global Solutions International B.V.
^P Presenting author

P-MODELS-27

Validation of skin and ocular irritation and severe damage (corrosion) tests as non-animal alternatives using OECD guideline evaluation substances

Paul Rawlinson¹, Matthew  Tate¹, Callum Stagg¹, Gary  Henzell¹, Elias Halkes-Wellstead^P1
1 Gentronix Ltd
^P Presenting author

P-MODELS-28

Vital human material as an innovative approach to move towards human-based science without animal research – What are the challenges ?

Cyrille Krul¹, Erin Hill^P2
1 University of applied sciences Utrecht
² Institute for In Vitro Sciences
^P Presenting author

P-MODELS-29

Perspective multi-modal acting compounds against SARS-COV-2 virus

J. Viskupicova ¹, P. Rezbarikova ¹, M. Soltesova Prnova ¹, H. Kandarova^P1, M. Majekova ^1
1 Centre of Experimental Medicine SAS, Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, SK-841 04 Bratislava, Slovak Republic
^P Presenting author

Go back

10. Nanoparticles research in vitro

P-NANO-1

ASSOCIATION OF DOXORUBICIN AND pH-SENSITIVE NANOPARTICLES CONTAINING AN ORGANOSELENIUM COMPOUND AS AN INNOVATIVE APPROACH TO SENSITIZE MDR CELLS: AN IN VITRO STUDY

Leticia B Macedo¹, Daniele R Nogueira-Librelotto¹, Daniela Mathes¹, Raquel Mello da Rosa², Oscar E Dorneles Rodrigues², Clarice M Bueno Rolim¹, M Pilar Vinardell^P3
1 Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil
² Programa de Pós-Graduação em Química, Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
³ Departament de Bioquimica i Fisiologia, Facultat de Farmacia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, Spain
^P Presenting author

P-NANO-2

Toxicity of polystyrene micro- and nano-plastics in human A549 lung cells

Marta Pennati¹, Judith Desmet¹, Tiantian Wang¹, Mahboubeh Hosseinzadeh¹, Cinta Porte^P1
1 IDAEA-CSIC
^P Presenting author

P-NANO-3

NEUROTOXICITY ASSESSMENT OF Cd/Se QUANTUM DOTS NANOPARTICLES IN T98G HUMAN GLIOBLASTOMA CELLS THROUGH A TRANSCRIPTOMIC APPROACH

Encarnación Fuster¹, Héctor Candela¹, Jorge Estévez¹, Eugenio Vilanova¹, Miguel A. Sogorb^P1
1 Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Avenida de la Universidad s/n, 03202 Elche, Spain
^P Presenting author

P-NANO-4

New development for studying the genotoxicity of nanomaterials in liver cell models

Julia VARET¹, Audrey BARRANGER¹, Camille CROCHET¹, Sylvie HUET¹, Ludovic LE HEGARAT¹, Valérie FESSARD^P1
1 Anses, Fougères laboratory, Toxicology of contaminants unit
^P Presenting author

P-NANO-5

INVOLVEMENT OF OXIDATIVE STRESS AND CALCIUM SIGNALING IN NICKEL OXIDE NANOPARTICLES – INDUCED ALTERATIONS IN HUMAN PULMONARY ARTERY ENDOTHELIAL CELLS

Ophélie Germande^P1,2, Sabrina Lacomme^3,2, Etienne Gontier^3,2, Jean – François Quignard^1,2, Roger Marthan^1,2,4, Magalie Baudrimont^5,2, Christelle Guibert^1,2, Juliette Deweirdt *^1,2, Isabelle Baudrimont *    *equal contribution^6,7
1 INSERM U 1045, CRCTB
² Université de Bordeaux
³ BIC, UMS 3420 CNRS – US4 INSERM
⁴ CHU de Bordeaux
⁵ UMR EPOC 5805
⁶ INSERM U 1045, CRCTB 
⁷ Université de Bordeaux 
^P Presenting author

P-NANO-6

Cytotoxicity of nanomixtures: effects of silver and polystyrene nanoparticles on human macrophages

Krunoslav Ilic^P1, Nikolina Kalcec¹, Lucija  Krce², Ivica  Aviani², Petra Turčić³, Ivan Pavičić¹, Ivana Vinkovic Vrcek^1
1 Institute for Medical Research and Occupational Health
² Faculty of Science, University of Split
³ Faculty of Pharmacy and Biochemistry, University of Zagreb
^P Presenting author

P-NANO-7

Erythrocyte photoassay as a preliminary tool to evaluate potential photoprotective activity of guarana-loaded nanosomes

Adriana Solange Maddaleno^P1, Isabel Roggia², Patrícia Gomes², Maria Pilar Vinardell¹, Montserrat Mitjans^1
1 Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona, Spain
² Post Graduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria, Brazil
^P Presenting author

P-NANO-8

Exposure to polystyrene micro- and nano-plastics modifies the lipidome of zebrafish liver cells.

Tiantian Wang^P1, Cinta Porte^1
1 IDAEA-CSIC
^P Presenting author

P-NANO-9

In vitro phototoxicity assessment of nanoparticles

Min Beom Heo^P1, In Young Kim¹, Tae Geol Lee^1
1 Korea Research Institute of Standards and Science
^P Presenting author

P-NANO-10

Effects of gold nanoparticles with protein corona on immune cell heterogeneity and cellular differentiation : A single cell based, high-dimensional mass cytometry study

Sehee Park^P1, My Ha², Sook Jin Kwon³, Yangsoon Lee¹, Jaewoo Song⁴, Tae Hyun Yoon^1,3
1 Hanyang University, Seoul, Republic of Korea
² Vaccine & Infectious Disease Institute, University of Antwerp, Belgium
³ Yoon Idea Lab. Co. Ltd, Seoul, Republic of Korea
⁴ Yonsei University, Seoul, Republic of Korea
^P Presenting author